The Adenomatous Polyposis coli protein:: The achilles heel of the gut epithelium

被引：177

作者：

Näthke, IS ^{[1
]}

机构：

[1] Univ Dundee, Dundee DD1 5EH, Scotland

来源：

ANNUAL REVIEW OF CELL AND DEVELOPMENTAL BIOLOGY | 2004年 / 20卷

关键词：

colon; cancer; migration; cytoskeleton; Wnt;

D O I：

10.1146/annurev.cellbio.20.012103.094541

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The Adenomatous Polyposis coli (APC) gene is mutated or lost in most colon cancers, and the APC protein has emerged as a multifunctional protein that is not only involved in the Wnt-regulated degradation of beta-catenin, but also regulates cytoskeletal proteins and thus plays a role in cell migration, cell adhesion, and mitosis. The gut epithelium is uniquely dependent on an intricate balance between a number of fundamental cellular processes including migration, differentiation, adhesion, apoptosis, and mitosis. In this review, I discuss the molecular mechanisms that govern the various functions of APC and their relationship to the role of APC in colon cancer.

引用

页码：337 / 366

页数：30

共 157 条

[11] The adenomatous polyposis coli-binding protein EB1 is associated with cytoplasmic and spindle microtubules [J].