Synthesis and potential coanthracyclinic activity of substituted 3-(5-imidazo[2,1-b]thiazolylmethylene)-2-indolinones

被引：17

作者：

Andreani, A

Locatelli, A

Leoni, A

Rambaldi, M

Morigi, R

Bossa, R

Chiericozzi, M

Fraccari, A

Galatulas, I

机构：

[1] Univ Bologna, Dipartimento Sci Farmaceut, I-40126 Bologna, Italy

[2] CTM, Dipartimento Farmacol, I-20129 Milan, Italy

来源：

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY | 1997年 / 32卷 / 11期

关键词：

imidazo[2,1-b]thiazotylmethylene-2-indolinones; cytotoxic activity; cardiotonic activity; coanthracyclinic activity;

D O I：

10.1016/S0223-5234(97)82778-X

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A compound endowed with coanthracyclinic activity should potentiate the antitumor activity of anthracyclines report the synthesis and configuration of a series of substituted while counteracting their cardiodepressant effect. We now the 3-(5-imidazo[2,1-b]thiazolylmethylene)-2-indolinones which were tested for both cardiotonic and cytotoxic activity. Several compounds were potent cytotoxic agents and two of them (in particular 3-[6-(2,5-dimethoxyphenyl)-5-imidazo[2,1-b]thiazolylmethylene]-2-indolinone), which showed even cardiotonic activity, are potential coanthracyclinic agents.

引用

页码：919 / 924

页数：6

共 14 条

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