A new approach to the synthesis of L-3-hydroxy-4-methoxy-5-methyl-phenylalanine derivatives from L-tyrosine

被引：30

作者：

Chen, Ruijiao ^{[1
]}

Zhu, Deguang ^{[1
]}

Hu, Zuoqiang ^{[1
]}

Zheng, Zhiming ^{[1
]}

Chen, Xiaochuan ^{[1
]}

机构：

[1] Sichuan Univ, Minist Educ, Key Lab Green Chem & Technol, Coll Chem, Chengdu 610064, Peoples R China

来源：

TETRAHEDRON-ASYMMETRY | 2010年 / 21卷 / 01期

基金：

中国国家自然科学基金;

关键词：

FORMAL TOTAL-SYNTHESIS; ECTEINASCIDIA-TURBINATA; CYANOSAFRACIN B; ET-743;

D O I：

10.1016/j.tetasy.2009.12.024

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

A practical procedure to regioselectively install a methyl group and a phenolic hydroxyl group onto L-tyrosine was developed. By using this approach, protected L-3-hydroxy-4-methoxy-5-methyl-phenylalanine and L-3-hydroxy-4-methoxy-5-methyl-phenylalanol, which are utilized in efficient syntheses of the relevant tetrahydroisoquinoline alkaloids, were prepared conveniently with high yield (c) 2010 Elsevier Ltd All rights reserved.

引用

页码：39 / 42

页数：4

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