Practical synthesis and elaboration of methyl 7-chloroindole-4-carboxylate

被引：11

作者：

Alper, PB ^{[1
]}

Nguyen, KT ^{[1
]}

机构：

[1] Novartis Fdn, Genom Inst, San Diego, CA 92121 USA

来源：

JOURNAL OF ORGANIC CHEMISTRY | 2003年 / 68卷 / 05期

关键词：

D O I：

10.1021/jo026434p

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A synthesis of a previously unknown indole derivative is presented. The route reported herein allows for the preparation of multihundred gram quantities of material without any chromatographic purification. Conditions are presented for the Pd-catalyzed elaboration of one of the "diversity generating elements" of this important pharmacophore.

引用

收藏

页码：2051 / 2053

页数：3

相关论文

共 66 条

[1]

[Anonymous], CHEM HETEROCYCLIC 4

[2] Synthesis of 2-oxindole derivatives via the intramolecular Heck reaction on solid support [J].

Arumugam, V ;

Routledge, A ;

Abell, C ;

Balasubramanian, S .

TETRAHEDRON LETTERS, 1997, 38 (36) :6473-6476

[3]

Balkenhohl F, 1996, ANGEW CHEM INT EDIT, V35, P2289

[4] INDOLE ALKALOIDS IN MEDICINE [J].

BAN, Y ;

MURAKAMI, Y ;

IWASAWA, Y ;

TSUCHIYA, M ;

TAKANO, N .

MEDICINAL RESEARCH REVIEWS, 1988, 8 (02) :231-308

[5] LSD - EFFECT ON MONOAMINE METABOLITES IN RAT PREFRONTAL CORTEX [J].

BOWERS, MB ;

SALOMONSSON, LA .

BIOCHEMICAL PHARMACOLOGY, 1982, 31 (24) :4093-4096

[6] 1,3,4,5-TETRAHYDROBENZ[CD]INDOLES AND RELATED COMPOUNDS .1. NEW SYNTHESIS OF 3,4-DIHYDROBENZ[CD]INDOL-5(1H)-ONE (UHLES KETONE) [J].

BOWMAN, RE ;

GOODBURN, TG ;

REYNOLDS, AA .

JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1, 1972, (9-10) :1121-&

[7] 4-(2-DI-NORMAL-PROPYLAMINOETHYL)-7-METHOXYINDOLE [J].

CANNON, JG ;

LUKSZO, J ;

MAX, GA .

JOURNAL OF HETEROCYCLIC CHEMISTRY, 1983, 20 (01) :149-153

[8] CHEMICAL-CONSTITUENTS OF AMARYLLIDACEAE .4. EFFECTS OF HIPPADINE, AN AMARYLLIDACEAE ALKALOID, ON TESTICULAR FUNCTION IN RATS [J].

CHATTOPADHYAY, S ;

CHATTOPADHYAY, U ;

MATHUR, PP ;

SAINI, KS ;

GHOSAL, S .

PLANTA MEDICA, 1983, 49 (04) :252-254

[9] Solid phase synthesis of spiroindoline [J].

Cheng, Y ;

Chapman, KT .

TETRAHEDRON LETTERS, 1997, 38 (09) :1497-1500

[10] METHYLTHIOMETHYLATION OF ANILINES AND PHENOLS .9. N-ARYL SULFIMIDES [J].

CLAUS, PK ;

RIEDER, W ;

HOFBAUER, P ;

VILSMAIER, E .

TETRAHEDRON, 1975, 31 (06) :505-510

← 1 2 3 4 5 6 7 →