Aziridination of alkenes with 3-acetoxyaminoquinazolinones in the presence of hexamethyldisilazane

被引：20

作者：

Atkinson, RS ^{[1
]}

Barker, E ^{[1
]}

Ulukanli, S ^{[1
]}

机构：

[1] Univ Leicester, Dept Chem, Leicester LE1 7RH, Leics, England

来源：

JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1 | 1998年 / 03期

关键词：

D O I：

10.1039/a704917j

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Yields of aziridines from reaction of some alkenes, including alpha,beta-unsaturated esters, with 3-acetoxyamino-2-isopropylquinazolinone 6 (Q(3)NHOAc) are greatly increased in the presence of hexamethyldisilazane (HMDS). A mono-aziridination product of naphthalene is obtained only in the presence of HMDS. It is concluded that the enhanced yields in these aziridinations are the result of scavenging of acetic acid by HMDS, thus prolonging the lifetime of the aziridinating agent Q(3)NHOAc.

引用

页码：583 / 589

页数：7

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