Highly diastereoselective aminoalkylation of naphthols with chiral amines mediated by lithium perchlorate solution in diethyl ether

被引：47

作者：

Saidi, MR ^{[1
]}

Azizi, N ^{[1
]}

机构：

[1] Sharif Univ Technol, Dept Chem, Tehran, Iran

来源：

TETRAHEDRON-ASYMMETRY | 2003年 / 14卷 / 03期

关键词：

D O I：

10.1016/S0957-4166(02)00863-7

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

One-pot, three-component, Mannich reaction of naphthols with in situ prepared imines in 5 M ethereal lithium perchlorate at room temperature affords the corresponding aminoalkylated products in high yields with high diastereoselectivities. The process is exemplified by the reaction of 2-naphthol with (R)-1-phenylethylamine and an aromatic aldehyde in concentrated ethereal lithium perchlorate solution, which affords a highly diastereoselective access to the requisite 2-aminoalkylated product. (C) 2003 Elsevier Science Ltd. All rights reserved.

引用

页码：389 / 392

页数：4

共 25 条

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