Host-Guest Interaction Mediated Polymeric Assemblies: Multifunctional Nanoparticles for Drug and Gene Delivery

被引：130

作者：

Zhang, Jianxiang ^{[1
]}

Sun, Hongli ^{[1
]}

Ma, Peter X. ^{[1
,2
,3
]}

机构：

[1] Univ Michigan, Dept Biol & Mat Sci, Ann Arbor, MI 48109 USA

[2] Univ Michigan, Macromol Sci & Engn Ctr, Ann Arbor, MI 48109 USA

[3] Univ Michigan, Dept Biomed Engn, Ann Arbor, MI 48109 USA

来源：

ACS NANO | 2010年 / 4卷 / 02期

关键词：

host-guest interactions; polymer assemblies; multifunctional nanoparticles; drug delivery; gene delivery; POLYION COMPLEX MICELLES; BLOCK-COPOLYMER; PHYSICOCHEMICAL PROPERTIES; SILICA NANOPARTICLES; DESIGNED FABRICATION; POLYPLEX MICELLES; SIRNA DELIVERY; PLASMID DNA; CANCER; FLUORESCENCE;

D O I：

10.1021/nn901213a

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Novel core-shell structured nanoassemblies are assembled by a beta-cyclodextrin containing a positively charged host polymer and a hydrophobic guest polymer. The hydrophobic core of these types of assemblies serves as a nanocontainer to load and release the hydrophobic drugs, while the positively charged hydrophilic shell is able to condense the plasmid DNA and achieve its transfection/expression in osteoblast cells. These assemblies may be used as a new generation of multifunctional nanocarriers for simultaneous drug delivery and gene therapy.

引用

页码：1049 / 1059

页数：11

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