Lipid rafts and B-cell activation

被引：263

作者：

Pierce, SK ^{[1
]}

机构：

[1] NIAID, NIH, Immunogenet Lab, Rockville, MD 20852 USA

来源：

NATURE REVIEWS IMMUNOLOGY | 2002年 / 2卷 / 02期

关键词：

D O I：

10.1038/nri726

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The B-cell antigen receptor acts during B-cell activation both to initiate signalling cascades and to transport antigen into the cell for subsequent processing and presentation. Recent evidence indicates that membrane microdomains, termed lipid rafts, have a role in B-cell activation as platforms for B-cell receptor (BCR) signalling and might also act in antigen trafficking. Lipid rafts might facilitate the regulation of the BCR during B-cell development by B-cell co-receptors, and during viral infection. So, lipid rafts seem to be an important new piece of the B-cell signalling puzzle.

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页码：96 / 105

页数：10

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