The EmrR protein represses the Escherichia coli emrRAB multidrug resistance operon by directly binding to its promoter region

被引：52

作者：

Xiong, A ^{[1
]}

Gottman, A ^{[1
]}

Park, C ^{[1
]}

Baetens, M ^{[1
]}

Pandza, S ^{[1
]}

Matin, A ^{[1
]}

机构：

[1] Stanford Univ, Sch Med, Dept Microbiol & Immunol, Stanford, CA 94305 USA

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2000年 / 44卷 / 10期

关键词：

D O I：

10.1128/AAC.44.10.2905-2907.2000

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

EmrR negatively regulates the transcription of the multidrug resistance pump-encoding operon, emrRAB, by binding to its regulatory region. The binding site spans the promoter and the downstream sequence up to the transcriptional start site of the operon. Structurally unrelated drugs that induce the pump interfere with this binding.

引用

页码：2905 / 2907

页数：3

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