学术探索
学术期刊
新闻热点
数据分析
智能评审

Forward and reverse genetic approaches to synaptogenesis

被引：20
作者：
Broadie, K [1 ]
机构：
[1] Univ Utah, Dept Biol, Salt Lake City, UT 84112 USA
来源：
CURRENT OPINION IN NEUROBIOLOGY | 1998年 / 8卷 / 01期
基金：
美国国家科学基金会; 美国国家卫生研究院;
关键词：
D O I：
10.1016/S0959-4388(98)80016-0
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
Genetic approaches at the neuromuscular synapse are leading investigation into the mechanisms of synaptogenesis. The marriage of classical (forward) and reverse genetic techniques allows the isolation and analysis of novel proteins involved in synaptic maturation and the functional in vivo characterization of previously identified synaptic proteins. Of particular interest are recent advances using mouse reverse genetics and Drosophila forward genetics.
引用
收藏
页码：128 / 138
页数：11
相关论文
共 64 条
  • [11] Colin I, 1996, J COMP NEUROL, V374, P467, DOI 10.1002/(SICI)1096-9861(19961021)374:3<467::AID-CNE10>3.0.CO
  • [12] 2-S
  • [13] Craig AM, 1996, J NEUROSCI, V16, P3166
  • [14] Genetic dissection of structural and functional components of synaptic plasticity .3. CREB is necessary for presynaptic functional plasticity
    Davis, GW
    Schuster, CM
    Goodman, CS
    [J]. NEURON, 1996, 17 (04) : 669 - 679
  • [15] The receptor tyrosine kinase MuSK is required for neuromuscular junction formation in vivo
    DeChiara, TM
    Bowen, DC
    Valenzuela, DM
    Simmons, MV
    Poueymirou, WT
    Thomas, S
    Kinetz, E
    Compton, DL
    Rojas, E
    Park, JS
    Smith, C
    DiStefano, PS
    Glass, DJ
    Burden, SJ
    Yancopoulos, GD
    [J]. CELL, 1996, 85 (04) : 501 - 512
  • [16] Utrophin-dystrophin-deficient mice as a model for Duchenne muscular dystrophy
    Deconinck, AE
    Rafael, JA
    Skinner, JA
    Brown, SC
    Potter, AC
    Metzinger, L
    Watt, DJ
    Dickson, JG
    Tinsley, JM
    Davies, KE
    [J]. CELL, 1997, 90 (04) : 717 - 727
  • [17] Postsynaptic abnormalities at the neuromuscular junctions of utrophin-deficient mice
    Deconinck, AE
    Potter, AC
    Tinsley, JM
    Wood, SJ
    Vater, R
    Young, C
    Metzinger, L
    Vincent, A
    Slater, CR
    Davies, KE
    [J]. JOURNAL OF CELL BIOLOGY, 1997, 136 (04) : 883 - 894
  • [18] GRIP: A synaptic PDZ domain-containing protein that interacts with AMPA receptors
    Dong, HL
    OBrien, RJ
    Fung, ET
    Lanahan, AA
    Worley, PF
    Huganir, RL
    [J]. NATURE, 1997, 386 (6622) : 279 - 284
  • [19] Crystal structures of a complexed and peptide-free membrane protein-binding domain: Molecular basis of peptide recognition by PDZ
    Doyle, DA
    Lee, A
    Lewis, J
    Kim, E
    Sheng, M
    MacKinnon, R
    [J]. CELL, 1996, 85 (07) : 1067 - 1076
  • [20] Agrin-induced acetylcholine receptor clustering in mammalian muscle requires tyrosine phosphorylation
    Ferns, M
    Deiner, M
    Hall, Z
    [J]. JOURNAL OF CELL BIOLOGY, 1996, 132 (05) : 937 - 944
1234567