Synthesis of six-membered nucleoside analogs .1. Pyrimidine nucleosides based on the 1,3-dioxane ring system

被引：6

作者：

Capaldi, DC

Eleuteri, A

Chen, Q

Schinazi, RF

机构：

[1] VET AFFAIRS MED CTR,MED RES 151,GEORGIA RES CTR AIDS & HIV INFECT,DECATUR,GA 30033

[2] EMORY UNIV,DEPT PEDIAT,ATLANTA,GA 30322

[3] EMORY UNIV,DEPT CHEM,ATLANTA,GA 30322

来源：

NUCLEOSIDES & NUCLEOTIDES | 1997年 / 16卷 / 04期

关键词：

D O I：

10.1080/07328319708001358

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The synthesis of pyrimidine nucleosides, cis-N-1-[(2-hydroxymethyl)-1,3-dioxan-5-yl]uracil (4) cis-N-1-[(2-hydroxymethyl)-1,3-dioxan-5-yl]thymine (5) and cis-N-1-[(2-hydroxymethyl)-1,3-dioxan-5-yl]cytosine (6) and their corresponding trans isomers is described. Compound 4 showed modest, selective activity against human immunodeficiency virus in acutely infected primary human lymphocytes.

引用

页码：403 / 416

页数：14

共 23 条

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