Value of 124I-PET/CT in staging of patients with differentiated thyroid cancer

被引：83

作者：

Freudenberg, LS

Antoch, G

Jentzen, W

Pink, R

Knust, J

Görges, R

Müller, SP

Bockisch, A

Debatin, JF

Brandau, W

机构：

[1] Univ Essen Gesamthsch, Clin & Policlin Nucl Med, D-45122 Essen, Germany

[2] Univ Essen Gesamthsch, Dept Radiol, Essen, Germany

来源：

EUROPEAN RADIOLOGY | 2004年 / 14卷 / 11期

关键词：

dual-modality; thyroid cancer; staging; PET; PET/CT; iodine-124; iodine-131; WBS;

D O I：

10.1007/s00330-004-2350-0

中图分类号：

R8 [特种医学]; R445 [影像诊断学];

学科分类号：

1002 ; 100207 ; 1009 ;

摘要：

The aim of this study is to evaluate the clinical significance of I-124 positron emission tomography (PET) using a combined PET/CT tomograph in patients with differentiated thyroid carcinoma and to compare the PET/CT results with I-131 whole-body scintigraphy (WBS), dedicated PET and CT alone, Twelve thyroid cancer patients were referred for diagnostic workup and entered complete clinical evaluation, including histology, cytology, thyroglobulin level, ultrasonography, fluorine-18 fluorodeoxyglucose (FDG)-PET, FDG-PET/CT and CT. Lesion-based evaluation showed a lesion delectability of 56, 87 and 100% for CT, I-124-PET, and combined I-124-PET/CT imaging, respectively. Lesion delectability of I-131-WBS was 83%. We conclude that I-124-PET/CT imaging is a promising technique to improve treatment planning in thyroid cancer. It is particularly valuable in patients suffering from advanced differentiated thyroid cancer prior to radio-iodine therapy and in patients with suspected recurrence and potential metastatic disease.

引用

页码：2092 / 2098

页数：7

共 24 条

[1]

Alnafisi NS, 2000, J NUCL MED, V41, P1010

[2]

[Anonymous], 1997, AJCC CANC STAGING MA

[3]

Beyer T, 2000, J NUCL MED, V41, P1369

[4]

Chung JK, 1999, J NUCL MED, V40, P986

[5] Thyroid volume measurement in thyrotoxic patients: comparison between ultrasonography and iodine-124 positron emission tomography [J].

Crawford, DC ;

Flower, MA ;

Pratt, BE ;

Hill, C ;

Zweit, J ;

McCready, R ;

Harmer, CL .

EUROPEAN JOURNAL OF NUCLEAR MEDICINE, 1997, 24 (12) :1470-1478

[6]

Erdi Yusuf E., 1999, Clin Positron Imaging, V2, P41, DOI 10.1016/S1095-0397(99)00004-7

[7]

ESCHMANN SM, 2000, EUR J NUCL MED, V29, P760

[8]

Filesi M, 1998, J NUCL MED, V39, P1542

[9] Combined PET/CT with iodine-124 in diagnosis of spread metastatic thyroid carcinoma:: a case report [J].

Freudenberg, LS ;

Antoch, G ;

Görges, R ;

Knust, J ;

Pink, R ;

Jentzen, W ;

Debatin, JF ;

Brandau, W ;

Bockisch, A ;

Stattaus, J .

EUROPEAN RADIOLOGY, 2003, 13 (Suppl 6) :L19-L23

[10] 124I-PET/CT in metastatic follicular thyroid carcinoma [J].

Freudenberg, LS ;

Antoch, G ;

Görges, R ;

Knust, EJ ;

Beyer, T ;

Brandau, W ;

Bockisch, A ;

Debatin, JF .

EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING, 2002, 29 (08) :1106-1106

← 1 2 3 →