Pd-catalyzed amination of nucleoside arylsulfonates to yield N6-aryl-2,6-diaminopurine nucleosides

被引：52

作者：

Gunda, P

Russon, LM

Lakshman, MK

机构：

[1] CUNY City Coll, Dept Chem, New York, NY 10031 USA

[2] Analyt Branford Inc, Branford, CT 06405 USA

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2004年 / 43卷 / 46期

关键词：

amination; C-C coupling; nucleosides; palladium; phosphane ligands;

D O I：

10.1002/anie.200460782

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

(Chemical equation presented). Substituents on both the nucleoside arylsulfonate as well as the aryl amine component have a significant impact on their coupling to form 2,6-diaminopurine-2′-deoxyribonucleosides (see scheme). A systematic study of ligands for the Pd catalysts in amination and C-C cross-coupling reactions gives insight into the structural elements that lead to effective catalysis.

引用

页码：6372 / 6377

页数：6

共 47 条

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