Hybrid silica nanoparticles for multimodal Imaging

被引：236

作者：

Rieter, William J.

Kim, Jason S.

Taylor, Kathryn M. L.

An, Hongyu

Lin, Weili

Tarrant, Teresa

Lin, Wenbin

机构：

[1] Univ N Carolina, Dept Chem, Chapel Hill, NC 27599 USA

[2] Univ N Carolina, Dept Radiol, Chapel Hill, NC 27599 USA

[3] Univ N Carolina, Dept Med, Chapel Hill, NC 27599 USA

[4] Univ N Carolina, Thurston Arthrit Res Ctr, Chapel Hill, NC 27599 USA

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2007年 / 46卷 / 20期

关键词：

gadolinium; imaging agents; magnetic resonance imaging; nanostructures; silicon;

D O I：

10.1002/anie.200604738

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

(Figure Presented) Lighting things up: Multifunctional silica nanoparticles containing a luminescent core and a paramagnetic coat are prepared, and their utility as multimodal imaging probes is demonstrated in vitro. Monocyte cells can be labeled with the hybrid nanoparticles with greater than 98% efficiency and do not experience measurable toxicity even at a high loading of 0.123 mg per 5000 cells. © 2007 Wiley-VCH Verlag GmbH & Co. KGaA.

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收藏

页码：3680 / 3682

页数：3

相关论文

共 20 条

[1] The use of nanocrystals in biological detection [J].

Alivisatos, P .

NATURE BIOTECHNOLOGY, 2004, 22 (01) :47-52

[2] Gadolinium(III) chelates as MRI contrast agents: Structure, dynamics, and applications [J].

Caravan, P ;

Ellison, JJ ;

McMurry, TJ ;

Lauffer, RB .

CHEMICAL REVIEWS, 1999, 99 (09) :2293-2352

[3] Nanotechnologies for biomolecular detection and medical diagnostics [J].

Cheng, MMC ;

Cuda, G ;

Bunimovich, YL ;

Gaspari, M ;

Heath, JR ;

Hill, HD ;

Mirkin, CA ;

Nijdam, AJ ;

Terracciano, R ;

Thundat, T ;

Ferrari, M .

CURRENT OPINION IN CHEMICAL BIOLOGY, 2006, 10 (01) :11-19

[4] In vivo cancer targeting and imaging with semiconductor quantum dots [J].

Gao, XH ;

Cui, YY ;

Levenson, RM ;

Chung, LWK ;

Nie, SM .

NATURE BIOTECHNOLOGY, 2004, 22 (08) :969-976

[5] Review - The fluorescent toolbox for assessing protein location and function [J].

Giepmans, BNG ;

Adams, SR ;

Ellisman, MH ;

Tsien, RY .

SCIENCE, 2006, 312 (5771) :217-224

[6] Some new developments in the synthesis, functionalization, and utilization of monodisperse colloidal spheres [J].

Jeong, U ;

Wang, YL ;

Ibisate, M ;

Xia, YN .

ADVANCED FUNCTIONAL MATERIALS, 2005, 15 (12) :1907-1921

[7] Engineering InAsxP1-x/InP/ZnSe III-V alloyed core/shell quantum dots for the near-infrared [J].

Kim, SW ;

Zimmer, JP ;

Ohnishi, S ;

Tracy, JB ;

Frangioni, JV ;

Bawendi, MG .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2005, 127 (30) :10526-10532

[8] The role of macrophages in rheumatoid arthritis [J].

Ma, YY ;

Pope, RM .

CURRENT PHARMACEUTICAL DESIGN, 2005, 11 (05) :569-580

[9] Targeted contrast agents for magnetic resonance imaging and ultrasound [J].

Morawski, AM ;

Lanza, GA ;

Wickline, SA .

CURRENT OPINION IN BIOTECHNOLOGY, 2005, 16 (01) :89-92

[10] A polyamidoamine dendrimer-capped mesoporous silica nanosphere-based gene transfection reagent [J].

Radu, DR ;

Lai, CY ;

Jeftinija, K ;

Rowe, EW ;

Jeftinija, S ;

Lin, VSY .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2004, 126 (41) :13216-13217