p53 in health and disease

被引：1793

作者：

Vousden, Karen H.

Lane, David P.

机构：

[1] Beatson Inst Canc Res, Glasgow G61 1BD, Lanark, Scotland

[2] Inst Mol & Cell Biol, Singapore 138673, Singapore

来源：

NATURE REVIEWS MOLECULAR CELL BIOLOGY | 2007年 / 8卷 / 04期

关键词：

D O I：

10.1038/nrm2147

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

As a component of the response to acute stress, p53 has a well established role in protecting against cancer development. However, it is now becoming clear that p53 can have a much broader role and can contribute to the development, life expectancy and overall fitness of an organism. Although the function of p53 as a tumour suppressor ensures that we can't live without it, an integrated view of p53 suggests that not all of its functions are conducive to a long and healthy life.

引用

收藏

页码：275 / 283

页数：9

相关论文

共 109 条

[1] HIGH-FREQUENCY DEVELOPMENTAL ABNORMALITIES IN P53-DEFICIENT MICE [J].

ARMSTRONG, JF ;

KAUFMAN, MH ;

HARRISON, DJ ;

CLARKE, AR .

CURRENT BIOLOGY, 1995, 5 (08) :931-936

[2] Perturbation of rRNA synthesis in the bap28 mutation leads to apoptosis mediated by p53 in the zebrafish central nervous system [J].

Azuma, M ;

Toyama, R ;

Laver, E ;

Dawid, IB .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2006, 281 (19) :13309-13316

[3]

Baatout S, 2002, IN VIVO, V16, P215

[4] p63 and epithelial biology [J].

Barbieri, CE ;

Pietenpol, JA .

EXPERIMENTAL CELL RESEARCH, 2006, 312 (06) :695-706

[5] DNA damage response as a candidate anti-cancer barrier in early human tumorigenesis [J].

Bartkova, J ;

Horejsi, Z ;

Koed, K ;

Krämer, A ;

Tort, F ;

Zieger, K ;

Guldberg, P ;

Sehested, M ;

Nesland, JM ;

Lukas, C ;

Orntoft, T ;

Lukas, J ;

Bartek, J .

NATURE, 2005, 434 (7035) :864-870

[6] Neuronal expression of p53 dominant-negative proteins in adult Drosophila melanogaster extends life span [J].

Bauer, JH ;

Poon, PC ;

Glatt-Deeley, H ;

Abrams, JM ;

Helfand, SL .

CURRENT BIOLOGY, 2005, 15 (22) :2063-2068

[7] New tricks of an old molecule: lifespan regulation by p53 [J].

Bauer, Johannes H. ;

Helfand, Stephen L. .

AGING CELL, 2006, 5 (05) :437-440

[8] Savior and slayer: the two faces of p53 [J].

Bensaad, K ;

Vousden, KH .

NATURE MEDICINE, 2005, 11 (12) :1278-1279

[9] TIGAR, a p53-inducible regulator of glycolysis and apoptosis [J].

Bensaad, Karim ;

Tsuruta, Atsushi ;

Selak, Mary A. ;

Calvo Vidal, M. Nieves ;

Nakano, Katsunori ;

Bartrons, Ramon ;

Gottlieb, Eyal ;

Vousden, Karen H. .

CELL, 2006, 126 (01) :107-120

[10] A single nucleotide polymorphism in the MDM2 promoter attenuates the p53 tumor suppressor pathway and accelerates tumor formation in humans [J].

Bond, GL ;

Hu, WW ;

Bond, EE ;

Robins, H ;

Lutzker, SG ;

Arva, NC ;

Bargonetti, J ;

Bartel, F ;

Taubert, H ;

Wuerl, P ;

Onel, K ;

Yip, L ;

Hwang, SJ ;

Strong, LC ;

Lozano, G ;

Levine, AJ .

CELL, 2004, 119 (05) :591-602

← 1 2 3 4 5 6 7 8 9 10 →