Synthesis and antiproliferative evaluation of 7-aminosubstituted pyrroloiminoquinone derivatives

被引：30

作者：

Bénéteau, V

Pierré, A

Pfeiffer, B

Renard, P

Besson, T

机构：

[1] Univ La Rochelle, Pole Sci & Technol, Lab Genie Prot & Cellulaire, F-17042 La Rochelle 1, France

[2] Inst Rech Servier, F-92150 Suresnes, France

[3] ADIR & Cie, F-92415 Courbevoie, France

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2000年 / 10卷 / 19期

关键词：

D O I：

10.1016/S0960-894X(00)00450-9

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Coupling of five amines on the 7-methoxy-1,3,4,5-tetrahydropyrrolo[4,3,2-de]quinoline core was achieved and afforded, in particular, an opened analogue of the natural alkaloid wakayin. Evaluation of cytotoxic activity of compounds 2, 10-13 on L1210 cells afforded IC50 in the range 0.25-5.3 mu M. (C) 2000 Elsevier Science Ltd. All rights reserved.

引用

页码：2231 / 2234

页数：4

共 17 条

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