Tripterygium wilfordii Inhibiting Angiogenesis for Rheumatoid Arthritis Treatment

被引：52

作者：

Zhang, Weisan ^{[1
,2
]}

Li, Fengtan ^{[3
]}

Gao, Wenyuan ^{[2
]}

机构：

[1] Tianjin Univ, Sch Pharmaceut Sci & Technol, Tianjin 300072, Peoples R China

[2] Tianjin Med Univ, Dept Geriatr, Gen Hosp, Tianjin 300020, Peoples R China

[3] Tianjin Med Univ, Dept Radiol, Gen Hosp, Tianjin 300020, Peoples R China

来源：

JOURNAL OF THE NATIONAL MEDICAL ASSOCIATION | 2017年 / 109卷 / 02期

关键词：

Tripterygium wilfordii; Hook f. (TwHf); Rheumatoid arthritis (RA); Angiogenesis; Vascular endothelial growth factor (VEGF); ENDOTHELIAL GROWTH-FACTOR; ENHANCED ANTITUMOR-ACTIVITY; HOOK-F; ANTIRHEUMATIC DRUGS; VEGF PRODUCTION; TRIPTOLIDE; CELASTROL; EXPRESSION; INTERLEUKIN-18; HIF-1-ALPHA;

D O I：

10.1016/j.jnma.2017.02.007

中图分类号：

R5 [内科学];

学科分类号：

100201 [内科学];

摘要：

Rheumatoid arthritis (RA) is a chronic inflammatory disease with a serious pre-vascular inflammatory phase, followed by significant increase in vessel growth. Inhibition of angiogenesis is a novel therapeutic strategy against RA. The Chinese herbal remedy Tripterygium wilfordii, Hook. f. (TwHf) has been reported to be therapeutically efficacious in the treatment of RA. Recent studies have revealed that treatment with TwHf extracts inhibit angiogenesis of RA, thereby elaborately attenuation RA symptom. This review mainly addresses the anti-angiogenesis effect of TwHf in treatment of RA.

引用

页码：142 / 148

页数：7

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