Polydopamine Nanoparticles as a Versatile Molecular Loading Platform to Enable Imaging-guided Cancer Combination Therapy

被引：331

作者：

Dong, Ziliang ^{[1
]}

Gong, Hua ^{[1
]}

Gao, Min ^{[1
]}

Zhu, Wenwen ^{[1
]}

Sun, Xiaoqi ^{[1
]}

Feng, Liangzhu ^{[1
]}

Fu, Tingting ^{[2
]}

Li, Yonggang ^{[2
]}

Liu, Zhuang ^{[1
]}

机构：

[1] Soochow Univ, Inst Funct Nano & Soft Mat FUNSOM, Collaborat Innovat Ctr Suzhou Nano Sci & Technol, Jiangsu Key Lab Carbon Based Funct Mat & Devices, Suzhou 215123, Jiangsu, Peoples R China

[2] Soochow Univ, Affiliated Hosp 1, Suzhou 215006, Jiangsu, Peoples R China

来源：

THERANOSTICS | 2016年 / 6卷 / 07期

基金：

中国国家自然科学基金;

关键词：

Polydopamine; Indocyanine green; Nano-Drug delivery system; Combination therapy; Magnetic resonance imaging; MESOPOROUS SILICA NANOPARTICLES; WALLED CARBON NANOTUBES; DEMAND DRUG-RELEASE; PHOTOTHERMAL THERAPY; INDOCYANINE GREEN; IRON-OXIDE; PHYSICOCHEMICAL CHARACTERIZATION; POLYPYRROLE NANOPARTICLES; MAGNETIC HYPERTHERMIA; THERANOSTIC AGENT;

D O I：

10.7150/thno.14431

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

100103 [病原生物学]; 100218 [急诊医学];

摘要：

Cancer combination therapy to treat tumors with different therapeutic approaches can efficiently improve treatment efficacy and reduce side effects. Herein, we develop a theranostic nano-platform based on polydopamine (PDA) nanoparticles, which then are exploited as a versatile carrier to allow simultaneous loading of indocyanine green (ICG), doxorubicin (DOX) and manganese ions (PDA-ICG-PEG/DOX(Mn)), to enable imaging-guided chemo & photothermal cancer therapy. In this system, ICG acts as a photothermal agent, which shows red-shifted near-infrared (NIR) absorbance and enhanced photostability compared with free ICG. DOX, a model chemotherapy drug, is then loaded onto the surface of PDA-ICG-PEG with high efficiency. With Mn2+ ions intrinsically chelated, PDA-ICG-PEG/DOX(Mn) is able to offer contrast under T1-weighted magnetic resonance (MR) imaging. In a mouse tumor model, the MR imaging-guided combined chemo- & photothermal therapy achieves a remarkable synergistic therapeutic effect compared with the respective single treatment modality. This work demonstrates that PDA nanoparticles could serve as a versatile molecular loading platform for MR imaging guided combined chemo- & photothermal therapy with minimal side effects, showing great potential for cancer theranostics.

引用

页码：1031 / 1042

页数：12

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