Tailor-Made Dual pH-Sensitive Polymer-Doxorubicin Nanoparticles for Efficient Anticancer Drug Delivery

被引:1163
作者
Du, Jin-Zhi [3 ,4 ]
Du, Xiao-Jiao [1 ,2 ]
Mao, Cheng-Qiong [1 ,2 ]
Wang, Jun [1 ,2 ]
机构
[1] Univ Sci & Technol China, CAS Key Lab Brain Funct & Dis, Hefei 230027, Anhui, Peoples R China
[2] Univ Sci & Technol China, Sch Life Sci, Hefei 230027, Anhui, Peoples R China
[3] Univ Sci & Technol China, CAS Key Lab Soft Matter Chem, Hefei 230026, Anhui, Peoples R China
[4] Univ Sci & Technol China, Dept Polymer Sci & Engn, Hefei 230026, Anhui, Peoples R China
基金
中国国家自然科学基金;
关键词
CANCER STEM-CELLS; SUPRAMOLECULAR ASSEMBLIES; CHARGE; MICELLES; NANOCARRIERS; CONJUGATE; DENDRIMER; DESIGN; TUMORS;
D O I
10.1021/ja207150n
中图分类号
O6 [化学];
学科分类号
070301 [无机化学];
摘要
Efficient delivery of therapeutics into tumor cells to increase the intracellular drug concentration is a major challenge for cancer therapy due to drug resistance and inefficient cellular uptake. Herein, we have designed a tailor-made dual pH-sensitive polymer drug conjugate nanoparticulate system to overcome the challenges. The nanoparticle is capable of reversing its surface charge from negative to positive at tumor extracellular pH (similar to 6.8) to facilitate cell internalization. Subsequently, the significantly increased acidity in subcellular compartments such as the endosome (similar to 5.0) further promotes doxorubicin release from the endocytosed drug carriers. This dual pH-sensitive nanoparticle has showed enhanced cytotoxicity in drug-resistant cancer stem cells, indicating its great potential for cancer therapy.
引用
收藏
页码:17560 / 17563
页数:4
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