Lessons learned from natural infection: focusing on the design of protective T cell vaccines for HIV/AIDS

被引：23

作者：

Ahlers, Jeffrey D. ^{[1
]}

Belyakov, Igor M. ^{[2
]}

机构：

[1] NIAID, NIH, Bethesda, MD 20817 USA

[2] Midwest Res Inst, Frederick, MD 21702 USA

来源：

TRENDS IN IMMUNOLOGY | 2010年 / 31卷 / 03期

关键词：

HUMAN-IMMUNODEFICIENCY-VIRUS; VIRAL REPLICATION CAPACITY; IMMUNE ESCAPE; MUCOSAL IMMUNIZATION; LYMPHOCYTE EPITOPES; ELITE CONTROLLERS; HIV-INFECTION; HIGH-AVIDITY; V-BETA; RESPONSES;

D O I：

10.1016/j.it.2009.12.003

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

CD8(+) cytotoxic T lymphocyte (CTL) responses are crucial in establishing the control of persistent virus infections. Population studies of HIV-1-infected individuals suggest that CD8(+) CTL responses targeting epitopes that take the greatest toll on virus replication are instrumental in immune control. A major question for vaccine design is whether incorporating epitopes responsible for controlling a persistent virus will translate into protection from natural infection or serve solely as a fail-safe mechanism to prevent overt disease in infected individuals. Here, we discuss qualitative parameters of the CD8(+) CTL response and mechanisms operative in the control of persistent virus infections and suggest new strategies for design and delivery of HIV vaccines.

引用

收藏

页码：120 / 130

页数：11

相关论文

共 116 条

[1] Preservation of functional virus-specific memory CD8+ T lymphocytes in vaccinated, simian human immunodeficiency virus-infected rhesus monkeys [J].

Acierno, Paula M. ;

Schmitz, Jorn E. ;

Gorgone, Darci A. ;

Sun, Yue ;

Santra, Sampa ;

Seaman, Michael S. ;

Newberg, Michael H. ;

Mascola, John R. ;

Nabel, Gary J. ;

Panicali, Dennis ;

Letvin, Norman L. .

JOURNAL OF IMMUNOLOGY, 2006, 176 (09) :5338-5345

[2] A push-pull approach to maximize vaccine efficacy: Abrogating suppression with an IL-13 inhibitor while augmenting help with granulocyte/macrophage colony-stimulating factor and CD40L [J].

Ahlers, JD ;

Belyakov, IM ;

Terabe, M ;

Koka, R ;

Donaldson, DD ;

Thomas, EK ;

Berzofsky, JA .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2002, 99 (20) :13020-13025

[3] High-affinity T helper epitope induces complementary helper and APC polarization, increased CTL, and protection against viral infection [J].

Ahlers, JD ;

Belyakov, IM ;

Thomas, EK ;

Berzofsky, JA .

JOURNAL OF CLINICAL INVESTIGATION, 2001, 108 (11) :1677-1685

[4] Strategies for recruiting and targeting dendritic cells for optimizing HIV vaccines [J].

Ahlers, Jeffrey D. ;

Belyakov, Igor M. .

TRENDS IN MOLECULAR MEDICINE, 2009, 15 (06) :263-274

[5] Impacts of epitope expression kinetics and class I downregulation on the antiviral activity of human immunodeficiency virus type 1-specific cytotoxic T lymphocytes [J].

Ali, A ;

Lubong, R ;

Ng, H ;

Brooks, DG ;

Zack, JA ;

Yang, OO .

JOURNAL OF VIROLOGY, 2004, 78 (02) :561-567

[6] Superior control of HIV-1 replication by CD8+ T cells is reflected by their avidity, polyfunctionality, and clonal turnover [J].

Almeida, Jorge R. ;

Price, David A. ;

Papagno, Laura ;

Arkoub, Zaina Ait ;

Sauce, Delphine ;

Bornstein, Ethan ;

Asher, Tedi E. ;

Samri, Assia ;

Schnuriger, Aurelie ;

Theodorou, Ioannis ;

Costagliola, Dominique ;

Rouzioux, Christine ;

Agut, Henri ;

Marcelin, Anne-Genevieve ;

Douek, Daniel ;

Autran, Brigitte ;

Appay, Victor .

JOURNAL OF EXPERIMENTAL MEDICINE, 2007, 204 (10) :2473-2485

[7] The majority of currently circulating human immunodeficiency virus type 1 clade B viruses fail to prime cytotoxic T-lymphocyte responses against an otherwise immunodominant HLA-A2-restricted epitope: Implications for vaccine design [J].

Altfeld, M ;

Allen, TM ;

Kalife, ET ;

Frahm, N ;

Addo, MM ;

Mothe, BR ;

Rathod, A ;

Reyor, LL ;

Harlow, J ;

Yu, XG ;

Perkins, B ;

Robinson, LK ;

Sidney, J ;

Alter, G ;

Lichterfeld, M ;

Sette, A ;

Rosenberg, ES ;

Goulder, PJR ;

Brander, C ;

Walker, BD .

JOURNAL OF VIROLOGY, 2005, 79 (08) :5000-5005

[8] Comparative Cell-Mediated Immunogenicity of DNA/DNA, DNA/Adenovirus Type 5 (Ad5), or Ad5/Ad5 HIV-1 Clade B gag Vaccine Prime-Boost Regimens [J].

Asmuth, David M. ;

Brown, Elizabeth L. ;

DiNubile, Mark J. ;

Sun, Xiao ;

del Rio, Carlos ;

Harro, Clayton ;

Keefer, Michael C. ;

Kublin, James G. ;

Dubey, Sheri A. ;

Kierstead, Lisa S. ;

Casimiro, Danilo R. ;

Shiver, John W. ;

Robertson, Michael N. ;

Quirk, Erin K. ;

Mehrotra, Devan V. .

JOURNAL OF INFECTIOUS DISEASES, 2010, 201 (01) :132-141

[9] How does HTLV-I persist despite a strong cell-mediated immune response? [J].

Asquith, Becca ;

Bangharn, Charles R. M. .

TRENDS IN IMMUNOLOGY, 2008, 29 (01) :4-11

[10] The Evolutionary Selective Advantage of HIV-1 Escape Variants and the Contribution of Escape to the HLA-Associated Risk of AIDS Progression [J].

Asquith, Becca .

PLOS ONE, 2008, 3 (10)

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