Synthesis of Botryllamides and Lansiumamides via Ruthenium-Catalyzed Hydroamidation of Alkynes

被引：21

作者：

Goossen, Lukas J. ^{[1
]}

Blanchot, Mathieu ^{[1
]}

Arndt, Matthias ^{[1
]}

Salih, Kifah S. M. ^{[1
]}

机构：

[1] TU Kaiserslautern, Inst Organ Chem, D-67663 Kaiserslautern, Germany

来源：

SYNLETT | 2010年 / 11期

关键词：

alkyne; botryllamide; hydroamidation; lansamide; lansiumamide; ruthenium; ANTI-MARKOVNIKOV-ADDITION; STEREOSELECTIVE-SYNTHESIS; TYROSINE DERIVATIVES; SELECTIVE ADDITION; ENAMIDES; AMIDES; INHIBITORS; ALDEHYDES; ETHERS;

D O I：

10.1055/s-0029-1219961

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Ruthenium-catalyzed hydroamidations of alkynes allow a concise synthetic entry to both E-and Z-configured enamide natural products. This was demonstrated by the synthesis of botryllamides C and E, lansiumamides A and B, and lansamide I in 1-3 steps and 57-98% yield from simple, commercially available precursors.

引用

页码：1685 / 1687

页数：3

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