Controlling Stem Cell Fate with Material Design

被引：208

作者：

Marklein, Ross A. ^{[1
]}

Burdick, Jason A. ^{[1
]}

机构：

[1] Univ Penn, Dept Bioengn, Philadelphia, PA 19104 USA

来源：

ADVANCED MATERIALS | 2010年 / 22卷 / 02期

基金：

美国国家科学基金会;

关键词：

HYALURONIC-ACID HYDROGELS; NEURAL PROGENITOR CELLS; INTERPENETRATING POLYMER NETWORKS; POLY(ETHYLENE GLYCOL) HYDROGELS; TISSUE ENGINEERING SCAFFOLDS; 3-DIMENSIONAL ALGINATE GELS; GROWTH-FACTOR DELIVERY; MARROW STROMAL CELLS; CHONDROGENIC DIFFERENTIATION; EMBRYOID BODIES;

D O I：

10.1002/adma.200901055

中图分类号：

O6 [化学];

学科分类号：

070301 [无机化学];

摘要：

Advances in our understanding of stem cell interactions with their environment are leading to the development of new materials-based approaches to control stem cell behavior toward cellular culture and tissue regeneration applications. Materials can provide cues based on chemistry, mechanics, structure, and molecule delivery that control stem cell fate decisions and matrix formation. These approaches are helping to advance clinical translation of a range of stem cell types through better expansion techniques and scaffolding for use in tissue engineering approaches for the regeneration of many tissues. With this in mind, this progress report covers basic concepts and recent advances in the use of materials for manipulating stem cells.

引用

页码：175 / 189

页数：15

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