Effect of melatonin on the oxidative stress in erythrocytes of healthy young and elderly subjects

被引:34
作者
Kedziora-Kornatowska, Kornelia
Szewczyk-Golec, Karolina
Czuczejko, Jolanta
de Lumen, Katarzyna van Marke
Pawluk, Hanna
Motyl, Jadwiga
Karasek, Michal
Kedziora, Jozef
机构
[1] Nicholas Copernicus Univ, Coll Med, Dept Biochem, PL-85092 Bydgoszcz, Poland
[2] Nicholas Copernicus Univ, Coll Med, Dept & Clin Geriatr, PL-85092 Bydgoszcz, Poland
[3] Med Univ Lodz, Dept Neuroendocrinol, PL-90131 Lodz, Poland
[4] Med Univ Lodz, Dept Clin Biochem, PL-90131 Lodz, Poland
关键词
aging; antioxidant enzymes; antioxidants; erythrocytes; melatonin; oxidative stress;
D O I
10.1111/j.1600-079X.2006.00394.x
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
The disturbances in pro- and antioxidant balance may play an important role in the pathomechanism of aging. The pineal hormone melatonin, which exerts effective antioxidative properties, is suggested to be involved in the aging process. The aim of this study was to compare the oxidative stress in erythrocytes of healthy young adults and elderly people, and to determine the influence of melatonin supplementation on measured parameters in both examined groups. The malondialdehyde (MDA) and reduced glutathione levels as well as Cu-Zn superoxide dismutase (SOD-1), catalase, glutathione peroxidase (GSH-Px), glutathione S-transferase (GST) and glutathione reductase (GR) activities in erythrocytes and morning serum melatonin concentration in 14 healthy young adults and 14 healthy elderly people at baseline and after the 30th day of melatonin (5 mg daily) supplementation were determined. A significant age effect on increasing the MDA level and decreasing SOD-1, GSH-Px and GR activities as well as melatonin concentration was observed. Melatonin supplementation resulted in a significant increase in melatonin concentration, SOD-1 and GR activities and a decrease in the MDA level in both examined groups. These data indicate an age-related augmentation of oxidative stress in erythrocytes and the improvement of erythrocytic antioxidative defense by melatonin administration. These results might suggest melatonin supplementation to prevent age-related diseases and to prolong the lifespan and improve the quality of life of elderly people.
引用
收藏
页码:153 / 158
页数:6
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