EFFECT OF THE DEGREE OF SUBSTITUTION OF (2-HYDROXY)PROPYL-BETA-CYCLODEXTRIN ON THE ENANTIOSEPARATION OF ORGANIC-ACIDS BY CAPILLARY ELECTROPHORESIS

被引：53

作者：

VALKO, IE ^{[1
]}

BILLIET, HAH ^{[1
]}

FRANK, J ^{[1
]}

LUYBEN, KCAM ^{[1
]}

机构：

[1] DELFT UNIV TECHNOL,KLUYVER LAB BIOTECHNOL,2628 BC DELFT,NETHERLANDS

来源：

JOURNAL OF CHROMATOGRAPHY A | 1994年 / 678卷 / 01期

关键词：

D O I：

10.1016/0021-9673(94)87083-7

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

Optical isomers of nine organic acids were separated by high-performance capillary electrophoresis using (2-hydroxy)propyl-beta-cyclodextrins, with a degree of the substitution between 3.0 and 7.3 (2-hydroxy)propyl groups/cyclodextrin molecule. The degree of substitution has a significant influence on the resolution of the enantiomers and is therefore an important tool in the optimisation of chiral separations. Accordingly, a proper description of derivatized cyclodextrins should include the degree of substitution.

引用

页码：139 / 144

页数：6

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