THE MECHANISM OF 1-METHYL-4-PHENYL-1,2,3,6-TETRAHYDROPYRIDINE TOXICITY - ROLE OF INTRACELLULAR CALCIUM

被引:88
作者
KASS, GEN [1 ]
WRIGHT, JM [1 ]
NICOTERA, P [1 ]
ORRENIUS, S [1 ]
机构
[1] KAROLINSKA INST,DEPT TOXICOL,BOX 60400,S-10401 STOCKHOLM 60,SWEDEN
关键词
D O I
10.1016/0003-9861(88)90509-7
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
引用
收藏
页码:789 / 797
页数:9
相关论文
共 50 条
[41]   UPTAKE OF THE NEUROTOXIN 1-METHYL-4-PHENYLPYRIDINE (MPP+) BY MITOCHONDRIA AND ITS RELATION TO THE INHIBITION OF THE MITOCHONDRIAL OXIDATION OF NAD+-LINKED SUBSTRATES BY MPP+ [J].
RAMSAY, RR ;
SALACH, JI ;
SINGER, TP .
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1986, 134 (02) :743-748
[42]   HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHY ANALYSIS OF NANOMOLE LEVELS OF GLUTATHIONE, GLUTATHIONE DISULFIDE, AND RELATED THIOLS AND DISULFIDES [J].
REED, DJ ;
BABSON, JR ;
BEATTY, PW ;
BRODIE, AE ;
ELLIS, WW ;
POTTER, DW .
ANALYTICAL BIOCHEMISTRY, 1980, 106 (01) :55-62
[43]   A SCHEME FOR THE COLORIMETRIC DETERMINATION OF MICROGRAM AMOUNTS OF THIOLS [J].
SAVILLE, B .
ANALYST, 1958, 83 (993) :670-672
[44]   INTERACTIONS OF THE NEUROTOXIC AMINE 1-METHYL-4-PHENYL-1,2,3,6-TETRAHYDROPYRIDINE WITH MONOAMINE OXIDASES [J].
SINGER, TP ;
SALACH, JI ;
CASTAGNOLI, N ;
TREVOR, A .
BIOCHEMICAL JOURNAL, 1986, 235 (03) :785-789
[45]   MPTP - A NEUROTOXIN RELEVANT TO THE PATHOPHYSIOLOGY OF PARKINSONS-DISEASE - THE 1985 COTZIAS,GEORGE,C. LECTURE [J].
SNYDER, SH ;
DAMATO, RJ .
NEUROLOGY, 1986, 36 (02) :250-258
[46]   OXIDATION AND ENZYME-ACTIVATED IRREVERSIBLE INHIBITION OF RAT-LIVER MONOAMINE OXIDASE-B BY 1-METHYL-4-PHENYL-1,2,3,6-TETRAHYDROPYRIDINE (MPTP) [J].
TIPTON, KF ;
MCCRODDEN, JM ;
YOUDIM, MBH .
BIOCHEMICAL JOURNAL, 1986, 240 (02) :379-383
[47]   BIOACTIVATION OF MPTP - REACTIVE METABOLITES AND POSSIBLE BIOCHEMICAL SEQUELAE [J].
TREVOR, AJ ;
CASTAGNOLI, N ;
CALDERA, P ;
RAMSAY, RR ;
SINGER, TP .
LIFE SCIENCES, 1987, 40 (08) :713-719
[48]  
TSOKOSKUHN JO, 1985, MOL PHARMACOL, V28, P56
[49]  
WRIGHT JM, 1984, NEW ENGL J MED, V310, P325
[50]   CHROMATIN CLEAVAGE IN APOPTOSIS - ASSOCIATION WITH CONDENSED CHROMATIN MORPHOLOGY AND DEPENDENCE ON MACROMOLECULAR-SYNTHESIS [J].
WYLLIE, AH ;
MORRIS, RG ;
SMITH, AL ;
DUNLOP, D .
JOURNAL OF PATHOLOGY, 1984, 142 (01) :67-77