PAIN, TENDERNESS, WHEAL AND FLARE INDUCED BY SUBSTANCE-P, BRADYKININ AND 5-HYDROXYTRYPTAMINE IN HUMANS

被引：29

作者：

JENSEN, K ^{[1
]}

TUXEN, C ^{[1
]}

PEDERSENBJERGAARD, U ^{[1
]}

JANSEN, I ^{[1
]}

机构：

[1] MALMO GEN HOSP,DEPT EXPTL RES,S-21401 MALMO,SWEDEN

来源：

CEPHALALGIA | 1991年 / 11卷 / 04期

关键词：

D O I：

10.1046/j.1468-2982.1991.1104175.x

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

The algesic effect of substance-P with and without the add on of bradykinin or 5-hydroxytryptamine was studied in 13 healthy volunteers. Test substances dissolved in saline were injected into the temporal muscle and the forearm skin and the effects compared with those of saline. In the temporal muscle, none of the test substances induced more pain than saline, but substance-P with bradykinin lowered the pressure pain threshold by 18% (p < 0.02). All test substances induced pain, wheal and flare in the forearm skin. Substance-P induced a more pronounced flare reaction than bradykinin, whereas the latter induced more pain than substance-P. This dissociation between pain and flare may indicate that C-fibres in the human skin represent more than one type of nociceptor.

引用

页码：175 / 182

页数：8

共 25 条

[11] LOCALIZATION AND EFFECTS OF NEUROPEPTIDE-Y, VASOACTIVE INTESTINAL POLYPEPTIDE, SUBSTANCE-P, AND CALCITONIN GENE RELATED PEPTIDE IN HUMAN TEMPORAL ARTERIES [J].