RESIDUES 20, 22, AND 26 DETERMINE THE SUBTYPE SPECIFICITIES OF STAPHYLOCOCCAL ENTEROTOXIN-C1 AND ENTEROTOXIN-C2

被引：18

作者：

TURNER, TN ^{[1
]}

SMITH, CL ^{[1
]}

BOHACH, GA ^{[1
]}

机构：

[1] UNIV IDAHO,DEPT BACTERIOL & BIOCHEM,MOSCOW,ID 83843

来源：

INFECTION AND IMMUNITY | 1992年 / 60卷 / 02期

关键词：

D O I：

10.1128/IAI.60.2.694-697.1992

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Nonconserved residues of staphylococcal enterotoxin C1 (SEC1) were converted to their counterparts in SEC2. The mutants that resulted were examined for reactivity with monoclonal antibodies (MAbs). Substitution at position 20, 22, or 26 interfered with binding of an SEC1-specific MAb. SEC1 mutants with substitutions at all three positions reacted only with an SEC2-specific MAb. Antibody-binding patterns were not associated with isoelectric point differences. All mutants retained biological activity.

引用

收藏

页码：694 / 697

页数：4

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