DEMONSTRATION OF INTERLEUKIN-2, INTERLEUKIN-4 AND INTERLEUKIN-6 IN SERA FROM PATIENTS WITH LOCALIZED SCLERODERMA

被引：92

作者：

IHN, H ^{[1
]}

SATO, S ^{[1
]}

FUJIMOTO, M ^{[1
]}

KIKUCHI, K ^{[1
]}

TAKEHARA, K ^{[1
]}

机构：

[1] UNIV TOKYO,FAC MED,DEPT DERMATOL,BUNKYO KU,TOKYO,JAPAN

来源：

ARCHIVES OF DERMATOLOGICAL RESEARCH | 1995年 / 287卷 / 02期

关键词：

LOCALIZED SCLERODERMA; INTERLEUKIN-2; INTERLEUKIN-4; INTERLEUKIN-6;

D O I：

10.1007/BF01262331

中图分类号：

R75 [皮肤病学与性病学];

学科分类号：

100206 ;

摘要：

Localized scleroderma has been reported to be accompanied by immunological abnormalities related to B cells, but little is known about T-cell activation in this disease, In this study, serum levels of interleukin-4 (IL-2), interleukin-4 (IL-4) and interleukin-6 (IL-6), which are known to be released by activated T cells, were determined using a sensitive enzyme-linked immunosorbent assay in 48 patients with localized scleroderma and 20 with systemic sclerosis, and in 20 healthy control subjects. IL-2, IL-4 and IL-6 were detected in serum from patients with localized scleroderma but not in that from healthy controls. The presence of antihistone antibodies correlated significantly with elevated IL-4 and IL-6 levels. Decreased serum levels of IL-2, IL-4 and IL-6 paralleled improvement in cutaneous sclerosis. Frequent detection of these lymphokines in serum from patients with localized scleroderma reflects T-cell activation in this disorder.

引用

页码：193 / 197

页数：5

共 41 条

[21] SELECTIVE INVITRO GROWTH OF T-LYMPHOCYTES FROM NORMAL HUMAN BONE MARROWS [J].

MORGAN, DA ;

RUSCETTI, FW ;

GALLO, R .

SCIENCE, 1976, 193 (4257) :1007-1008

[22] INTERLEUKIN-1, INTERLEUKIN-2, INTERLEUKIN-4, INTERLEUKIN-6, TUMOR-NECROSIS-FACTOR-ALPHA, AND INTERFERON-GAMMA LEVELS IN SERA FROM PATIENTS WITH SCLERODERMA [J].

NEEDLEMAN, BW ;

WIGLEY, FM ;

STAIR, RW .

ARTHRITIS AND RHEUMATISM, 1992, 35 (01) :67-72

[23]

PALIARD X, 1988, J IMMUNOL, V141, P849

[24] HUMAN FIBROBLASTS SYNTHESIZE ELEVATED LEVELS OF EXTRACELLULAR-MATRIX PROTEINS IN RESPONSE TO INTERLEUKIN-4 [J].

POSTLETHWAITE, AE ;

HOLNESS, MA ;

KATAI, H ;

RAGHOW, R .

JOURNAL OF CLINICAL INVESTIGATION, 1992, 90 (04) :1479-1485

[25]

Preliminary criteria for the classification of systemic sclerosis (scleroderma), 1980, ARTHRITIS RHEUM, V5, P581

[26] CUTANEOUS COLLAGENOSIS [J].

REED, RJ ;

CLARK, WH ;

MIHM, MC .

HUMAN PATHOLOGY, 1973, 4 (02) :165-186

[27]

RODNAN GP, 1977, ARTHRITIS RHEUM, V20, P133

[28]

RODNAN GR, 1981, B RHEUM DIS, V31, P7

[29]

RUSCETTI FW, 1977, J IMMUNOL, V119, P131

[30] ANTIHISTONE ANTIBODIES IN PATIENTS WITH LOCALIZED SCLERODERMA [J].

SATO, S ;

IHN, H ;

SOMA, Y ;

IGARASHI, A ;

TAMAKI, T ;

KIKUCHI, K ;

ISHIBASHI, Y ;

TAKEHARA, K .

ARTHRITIS AND RHEUMATISM, 1993, 36 (08) :1137-1141

← 1 2 3 4 5 →