TOPLISS APPROACH TO THE SYNTHESIS OF BIOLOGICALLY-ACTIVE SUBSTITUTED N-BENZOYL TAXOL ANALOGS

被引：16

作者：

GEORG, GI ^{[1
]}

BOGE, TC ^{[1
]}

CHERUVALLATH, ZS ^{[1
]}

HARRIMAN, GCB ^{[1
]}

HEPPERLE, M ^{[1
]}

PARK, H ^{[1
]}

HIMES, RH ^{[1
]}

机构：

[1] UNIV KANSAS,DEPT BIOCHEM,LAWRENCE,KS 66045

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1994年 / 4卷 / 15期

关键词：

D O I：

10.1016/S0960-894X(01)80378-4

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A series of compounds, directed by the Topliss Operational Scheme, were synthesized and evaluated to investigate structure activity relationships of the N-benzoyl moiety of taxol. Evaluation of the newly prepared derivatives in the microtubule assembly assay and for cytotoxicity revealed that they possessed biological properties similar to taxol.

引用

页码：1825 / 1830

页数：6

共 45 条

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