TOPLISS APPROACH TO THE SYNTHESIS OF BIOLOGICALLY-ACTIVE SUBSTITUTED N-BENZOYL TAXOL ANALOGS

被引：16

作者：

GEORG, GI ^{[1
]}

BOGE, TC ^{[1
]}

CHERUVALLATH, ZS ^{[1
]}

HARRIMAN, GCB ^{[1
]}

HEPPERLE, M ^{[1
]}

PARK, H ^{[1
]}

HIMES, RH ^{[1
]}

机构：

[1] UNIV KANSAS,DEPT BIOCHEM,LAWRENCE,KS 66045

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1994年 / 4卷 / 15期

关键词：

D O I：

10.1016/S0960-894X(01)80378-4

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A series of compounds, directed by the Topliss Operational Scheme, were synthesized and evaluated to investigate structure activity relationships of the N-benzoyl moiety of taxol. Evaluation of the newly prepared derivatives in the microtubule assembly assay and for cytotoxicity revealed that they possessed biological properties similar to taxol.

引用

页码：1825 / 1830

页数：6

共 45 条

[41] BIOLOGICALLY-ACTIVE TAXOL ANALOGS WITH DELETED A-RING SIDE-CHAIN SUBSTITUENTS AND VARIABLE C-2' CONFIGURATIONS
SWINDELL, CS
KRAUSS, NE
HORWITZ, SB
RINGEL, I
[J]. JOURNAL OF MEDICINAL CHEMISTRY, 1991, 34 (03) : 1176 - 1184
[42] MANUAL METHOD FOR APPLYING HANSCH APPROACH TO DRUG DESIGN
TOPLISS, JG
[J]. JOURNAL OF MEDICINAL CHEMISTRY, 1977, 20 (04) : 463 - 469
[43] UTILIZATION OF OPERATIONAL SCHEMES FOR ANALOG SYNTHESIS IN DRUG DESIGN
TOPLISS, JG
[J]. JOURNAL OF MEDICINAL CHEMISTRY, 1972, 15 (10) : 1006 - &
[44] CYANURIC CHLORIDE - USEFUL REAGENT FOR CONVERTING CARBOXYLIC-ACIDS INTO CHLORIDES, ESTERS, AMIDES AND PEPTIDES
VENKATARAMAN, K
WAGLE, DR
[J]. TETRAHEDRON LETTERS, 1979, (32) : 3037 - 3040
[45] PLANT ANTITUMOR AGENTS .6. ISOLATION AND STRUCTURE OF TAXOL, A NOVEL ANTILEUKEMIC AND ANTITUMOR AGENT FROM TAXUS-BREVIFOLIA
WANI, MC
TAYLOR, HL
WALL, ME
COGGON, P
MCPHAIL, AT
[J]. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1971, 93 (09) : 2325 - &

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