DEXTROMETHORPHAN O-DEMETHYLATION IN LIVER-MICROSOMES AS A PROTOTYPE REACTION TO MONITOR CYTOCHROME-P-450 DB1 ACTIVITY

被引:129
作者
DAYER, P
LEEMANN, T
STRIBERNI, R
机构
关键词
D O I
10.1038/clpt.1989.6
中图分类号
R9 [药学];
学科分类号
1007 ;
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页码:34 / 40
页数:7
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[1]   IMPORTANCE OF OXIDATIVE POLYMORPHISM AND LEVOMEPROMAZINE TREATMENT ON THE STEADY-STATE BLOOD-CONCENTRATIONS OF CLOMIPRAMINE AND ITS MAJOR METABOLITES [J].
BALANTGORGIA, AE ;
BALANT, LP ;
GENET, C ;
DAYER, P ;
AESCHLIMANN, JM ;
GARRONE, G .
EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY, 1986, 31 (04) :449-455
[2]   NORTRIPTYLINE AND ANTIPYRINE CLEARANCE IN RELATION TO DEBRISOQUINE HYDROXYLATION IN MAN [J].
BERTILSSON, L ;
EICHELBAUM, M ;
MELLSTROM, B ;
SAWE, J ;
SCHULZ, HU ;
SJOQVIST, F .
LIFE SCIENCES, 1980, 27 (18) :1673-1677
[3]   GENETIC-POLYMORPHISM IN DRUG OXIDATION - INVITRO STUDIES OF HUMAN DEBRISOQUINE 4-HYDROXYLASE AND BUFURALOL 1'-HYDROXYLASE ACTIVITIES [J].
BOOBIS, AR ;
MURRAY, S ;
HAMPDEN, CE ;
DAVIES, DS .
BIOCHEMICAL PHARMACOLOGY, 1985, 34 (01) :65-71
[4]   GENETICALLY-DETERMINED VARIABILITY IN ACETYLATION AND OXIDATION - THERAPEUTIC IMPLICATIONS [J].
CLARK, DWJ .
DRUGS, 1985, 29 (04) :342-375
[5]   EVIDENCE FOR AN ENZYMATIC DEFECT IN THE 4-HYDROXYLATION OF DEBRISOQUINE BY HUMAN-LIVER [J].
DAVIES, DS ;
KAHN, GC ;
MURRAY, S ;
BRODIE, MJ ;
BOOBIS, AR .
BRITISH JOURNAL OF CLINICAL PHARMACOLOGY, 1981, 11 (01) :89-91
[6]   CHARACTERIZATION OF A COMMON GENETIC-DEFECT OF CYTOCHROME-P-450 FUNCTION (DEBRISOQUINE-SPARTEINE TYPE POLYMORPHISM) - INCREASED MICHAELIS CONSTANT (KM) AND LOSS OF STEREOSELECTIVITY OF BUFURALOL 1'-HYDROXYLATION IN POOR METABOLIZERS [J].
DAYER, P ;
GASSER, R ;
GUT, J ;
KRONBACH, T ;
ROBERTZ, GM ;
EICHELBAUM, M ;
MEYER, UA .
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1984, 125 (01) :374-380
[7]   ENZYMATIC BASIS OF THE DEBRISOQUINE SPARTEINE-TYPE GENETIC-POLYMORPHISM OF DRUG OXIDATION - CHARACTERIZATION OF BUFURALOL 1'-HYDROXYLATION IN LIVER-MICROSOMES OF INVIVO PHENOTYPED CARRIERS OF THE GENETIC DEFICIENCY [J].
DAYER, P ;
KRONBACH, T ;
EICHELBAUM, M ;
MEYER, UA .
BIOCHEMICAL PHARMACOLOGY, 1987, 36 (23) :4145-4152
[8]   BIOACTIVATION OF THE NARCOTIC DRUG CODEINE IN HUMAN-LIVER IS MEDIATED BY THE POLYMORPHIC MONOOXYGENASE CATALYZING DEBRISOQUINE 4-HYDROXYLATION (CYTOCHROME-P-450 DBL/BUFI) [J].
DAYER, P ;
DESMEULES, J ;
LEEMANN, T ;
STRIBERNI, R .
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1988, 152 (01) :411-416
[9]   DEFECTIVE HYDROXYLATION OF BUFURALOL ASSOCIATED WITH SIDE-EFFECTS OF THE DRUG IN POOR METABOLIZERS [J].
DAYER, P ;
KUBLI, A ;
KUPFER, A ;
COURVOISIER, F ;
BALANT, L ;
FABRE, J .
BRITISH JOURNAL OF CLINICAL PHARMACOLOGY, 1982, 13 (05) :750-752
[10]   CHARACTERIZATION OF A HUMAN-LIVER CYTOCHROME-P-450 INVOLVED IN THE OXIDATION OF DEBRISOQUINE AND OTHER DRUGS BY USING ANTIBODIES RAISED TO THE ANALOGOUS RAT ENZYME [J].
DISTLERATH, LM ;
GUENGERICH, FP .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES, 1984, 81 (23) :7348-7352