DIRECT, STEREOSELECTIVE SYNTHESIS OF THE PROTECTED PACLITAXEL (TAXOL) SIDE-CHAIN AND HIGH-YIELD TRANSFORMATION TO PACLITAXEL

被引：30

作者：

KANAZAWA, AM ^{[1
]}

DENIS, JN ^{[1
]}

GREENE, AE ^{[1
]}

机构：

[1] UNIV GRENOBLE 1,CHIM RECH LEDSS,F-38041 GRENOBLE,FRANCE

来源：

JOURNAL OF THE CHEMICAL SOCIETY-CHEMICAL COMMUNICATIONS | 1994年 / 22期

关键词：

D O I：

10.1039/c39940002591

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A short, efficient approach to the p-methoxybenzylidene-protected paclitaxel (Taxol) side chain through benzaldehyde benzoylimine-chiraol enolate condensation, followed by DDQ-mediated oxazolidine formation and hydrolysis is described; the C-7-triethylsilyl derivative of baccatin III undergoes esterification with this side chain in the presence of DCC and DMAP to provide after acid hydrolysis paclitaxel in excellent overall yield.

引用

页码：2591 / 2592

页数：2

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