PERIPHERAL PROJECTIONS OF RAT PRIMARY SENSORY NEURONS IMMUNOREACTIVE FOR NEUROTROPHIN-3

被引:23
作者
ZHOU, XF [1 ]
RUSH, RA [1 ]
机构
[1] FLINDERS UNIV S AUSTRALIA,DEPT HUMAN PHYSIOL,ADELAIDE,SA 5001,AUSTRALIA
关键词
NEUROTROPHIC FACTORS; SENSORY MODALITY; INNERVATION; MUSCLE; IMMUNOHISTOCHEMISTRY;
D O I
10.1002/cne.903630107
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Sensory neurons can be classified into subpopulations based on a variety of characteristics, including their morphology and physiological modalities. Whether any of these classifications correlates with neurotrophic sensitivities has not been determined. We have recently reported that a subpopulation of large diameter sensory neurons of the rat contain neurotrophin 3-like immunoreactivity (NT3-ir). In this study, we have further characterised NT3-ir sensory neurons by their size, segmental localization, and peripheral projections by combined techniques of retrograde tracing and immunohistochemistry. The size distribution showed that NT3-ir was localised to a subpopulation of large-diameter neurons ranging from 560 to 3,120 mu m(2). Greater numbers of NT3-ir neurons reside in trigeminal (43% of total), cervical (36%), and lumbar (39%) than in thoracic spinal ganglia (13-17%). In combination with Fluoro-Gold retrograde tracing, it was found that about 30% of sensory neurons projecting to the tibial muscle were NT3-ir, compared with 39% for tendon, 50% for whisker hair follicles, 17% for subdermis or epidermis, and only 1% for kidney or adrenal gland. These studies indicate that NT3-ir sensory neurons mainly project to skin and muscles but not viscera. Thus, the characterization of NT3-ir spinal sensory neurons suggests that large sensory neurons subserving proprioception and mechanoception require NT3 for the maintenance of normal function. (C) 1995 Wiley-Liss, Inc.
引用
收藏
页码:69 / 77
页数:9
相关论文
共 54 条
[31]  
LINDSAY RM, 1988, J NEUROSCI, V8, P2394
[32]   NEUROTROPHIN-3 - A NEUROTROPHIC FACTOR RELATED TO NGF AND BDNF [J].
MAISONPIERRE, PC ;
BELLUSCIO, L ;
SQUINTO, S ;
IP, NY ;
FURTH, ME ;
LINDSAY, RM ;
YANCOPOULOS, GD .
SCIENCE, 1990, 247 (4949) :1446-1451
[33]   NT-3, BDNF, AND NGF IN THE DEVELOPING RAT NERVOUS-SYSTEM - PARALLEL AS WELL AS RECIPROCAL PATTERNS OF EXPRESSION [J].
MAISONPIERRE, PC ;
BELLUSCIO, L ;
FRIEDMAN, B ;
ALDERSON, RF ;
WIEGAND, SJ ;
FURTH, ME ;
LINDSAY, RM ;
YANCOPOULOS, GD .
NEURON, 1990, 5 (04) :501-509
[34]   EXPRESSION AND COEXPRESSION OF TRK RECEPTORS IN SUBPOPULATIONS OF ADULT PRIMARY SENSORY NEURONS PROJECTING TO IDENTIFIED PERIPHERAL TARGETS [J].
MCMAHON, SB ;
ARMANINI, MP ;
LING, LH ;
PHILLIPS, HS .
NEURON, 1994, 12 (05) :1161-1171
[35]  
MU XJ, 1993, J NEUROSCI, V13, P4029
[36]   REQUIREMENT FOR NERVE GROWTH-FACTOR IN THE DEVELOPMENT OF MYELINATED NOCICEPTORS INVIVO [J].
RITTER, AM ;
LEWIN, GR ;
KREMER, NE ;
MENDELL, LM .
NATURE, 1991, 350 (6318) :500-502
[37]   THE SURVIVAL OF CHICK RETINAL GANGLION-CELLS IN RESPONSE TO BRAIN-DERIVED NEUROTROPHIC FACTOR DEPENDS ON THEIR EMBRYONIC AGE [J].
RODRIGUEZTEBAR, A ;
JEFFREY, PL ;
THOENEN, H ;
BARDE, YA .
DEVELOPMENTAL BIOLOGY, 1989, 136 (02) :296-303
[38]   PRIMARY STRUCTURE AND BIOLOGICAL-ACTIVITY OF A NOVEL HUMAN NEUROTROPHIC FACTOR [J].
ROSENTHAL, A ;
GOEDDEL, DV ;
NGUYEN, T ;
LEWIS, M ;
SHIH, A ;
LARAMEE, GR ;
NIKOLICS, K ;
WINSLOW, JW .
NEURON, 1990, 4 (05) :767-773
[39]   SELECTIVE DEPENDENCE OF MAMMALIAN DORSAL-ROOT GANGLION NEURONS ON NERVE GROWTH-FACTOR DURING EMBRYONIC-DEVELOPMENT [J].
RUIT, KG ;
ELLIOTT, JL ;
OSBORNE, PA ;
YAN, Q ;
SNIDER, WD .
NEURON, 1992, 8 (03) :573-587
[40]   DEPENDENCE OF KIDNEY MORPHOGENESIS ON THE EXPRESSION OF NERVE GROWTH-FACTOR RECEPTOR [J].
SARIOLA, H ;
SAARMA, M ;
SAINIO, K ;
ARUMAE, U ;
PALGI, J ;
VAAHTOKARI, A ;
THESLEFF, I ;
KARAVANOV, A .
SCIENCE, 1991, 254 (5031) :571-573