SYNTHESIS AND RELEASE OF DOXORUBICIN FROM A CEPHALOSPORIN BASED PRODRUG BY A BETA-LACTAMASE-IMMUNOCONJUGATE

被引：27

作者：

HUDYMA, TW

BUSH, K

COLSON, KL

FIRESTONE, RA

KING, HD

机构：

[1] BRISTOL MYERS SQUIBB CO,PHARMACEUT RES INST,DEPT MICROBIOL,WALLINGFORD,CT 06492

[2] BRISTOL MYERS SQUIBB CO,PHARMACEUT RES INST,DEPT ANALYT RES,WALLINGFORD,CT 06492

[3] BRISTOL MYERS SQUIBB CO,PRINCETON,NJ 08543

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1993年 / 3卷 / 02期

关键词：

D O I：

10.1016/S0960-894X(01)80902-1

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A cephalosporin based prodrug of doxorubicin has been synthesized which efficiently releases doxorubicin in the presence of an immunoconjugate consisting of a beta-lactamase-MAb.

引用

页码：323 / 328

页数：6

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