COMPARISON OF THE RETENTION BEHAVIOR OF PHENOL DERIVATIVES ON POROUS GRAPHITIZED AND OCTADECYLSILICA COLUMNS

被引：35

作者：

FORGACS, E ^{[1
]}

CSERHATI, T ^{[1
]}

BORDAS, B ^{[1
]}

机构：

[1] HUNGARIAN ACAD SCI,INST PLANT PROTECT,H-1361 BUDAPEST 5,HUNGARY

来源：

CHROMATOGRAPHIA | 1993年 / 36卷

关键词：

COLUMN LIQUID CHROMATOGRAPHY; STRUCTURE-RETENTION RELATIONSHIPS; MATHEMATICAL DATA ANALYSIS; PHENOL DERIVATIVES; ODS AND GRAPHITIZED CARBON COLUMNS;

D O I：

10.1007/BF02263830

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

The retention of 22 ring-substituted phenol derivatives on porous graphitized carbon (PGC) (eluents: acetonitrile - water and methanol - water mixtures) and on octadecylsilica (ODS) (eluents: methanol - 0.025 M KH2PO4 mixtures) was determined, and the relationship between retention and physicochemical parameters were evaluated by principal component analysis followed by two-dimensional nonlinear mapping and by cluster analysis as well as by canonical correlation analysis. Calculations proved that marked differences can be detected between the retention characteristics of PGC and ODS columns, and the electronic parameters of phenol derivatives have the highest impact on their retention. The comparison of various multivariate mathematical-statistical methods indicated that principal component analysis followed by two dimensional non-linear mapping is the most appropriate method for the evaluation of large data matrices in RP-HPLC.

引用

页码：19 / 26

页数：8

共 34 条

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