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SYNTHETIC STUDIES ON QUINOCARCIN AND ITS RELATED-COMPOUNDS .5. SYNTHESIS AND ANTITUMOR-ACTIVITY OF VARIOUS STRUCTURAL TYPES OF QUINOCARCIN CONGENERS

被引：13
作者：
KATOH, T
KIRIHARA, M
YOSHINO, T
TAMURA, O
IKEUCHI, F
NAKATANI, K
MATSUDA, F
YAMADA, K
GOMI, K
ASHIZAWA, T
TERASHIMA, S
机构：
[1] SAGAMI CHEM RES CTR,SAGAMIHARA,KANAGAWA 229,JAPAN
[2] KYOWA HAKKO KOGYO CO LTD,PHARMACEUT RES LABS,NAGAIZUMI,SHIZUOKA 411,JAPAN
来源：
TETRAHEDRON | 1994年 / 50卷 / 21期
关键词：
QUINOCARCIN; QUINOCARCIN CONGENERS; CYTOTOXICITY; ANTITUMOR ACTIVITY; STRUCTURE-ACTIVITY RELATIONSHIPS;
D O I：
10.1016/S0040-4020(01)80645-1
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
The antitumor activity of various structural types of quinocarcin congeners which had been previously prepared in the course of our synthetic studies or were originally synthesized by employing novel synthetic schemes, was primarily evaluated by in vitro cytotoxicity assay against P388 murine leukemia cells. Several compounds exhibiting prominent cytotoxicity were selected, and further subjected to in vitro cytotoxicity assay against HeLa S3 cells and to in vivo antitumor activity assay against P388 murine leukemia. These studies obviously disclosed novel aspects of the structure-activity relationships of quinocarcin congeners.
引用
收藏
页码：6259 / 6270
页数：12
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