DRUG DESIGN BY THE METHOD OF RECEPTOR FIT

被引：68

作者：

GOODFORD, PJ

机构：

来源：

JOURNAL OF MEDICINAL CHEMISTRY | 1984年 / 27卷 / 05期

关键词：

D O I：

10.1021/jm00371a001

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

引用

页码：557 / 564

页数：8

共 59 条

[41] A GEOMETRIC APPROACH TO MACROMOLECULE-LIGAND INTERACTIONS [J].

KUNTZ, ID ;

BLANEY, JM ;

OATLEY, SJ ;

LANGRIDGE, R ;

FERRIN, TE .

JOURNAL OF MOLECULAR BIOLOGY, 1982, 161 (02) :269-288

[42] RECEPTOR-BASED DESIGN OF DIHYDROFOLATE-REDUCTASE INHIBITORS - COMPARISON OF CRYSTALLOGRAPHICALLY DETERMINED ENZYME BINDING WITH ENZYME AFFINITY IN A SERIES OF CARBOXY-SUBSTITUTED TRIMETHOPRIM ANALOGS [J].

KUYPER, LF ;

ROTH, B ;

BACCANARI, DP ;

FERONE, R ;

BEDDELL, CR ;

CHAMPNESS, JN ;

STAMMERS, DK ;

DANN, JG ;

NORRINGTON, FEA ;

BAKER, DJ ;

GOODFORD, PJ .

JOURNAL OF MEDICINAL CHEMISTRY, 1982, 25 (10) :1120-1122

[43] 3-DIMENSIONAL STRUCTURES AND CHEMICAL MECHANISMS OF ENZYMES [J].

LIPSCOMB, WN .

CHEMICAL SOCIETY REVIEWS, 1972, 1 (03) :319-+

[44] INTERPRETATION OF NUCLEAR MAGNETIC-RESONANCE SPECTRA FOR LACTOBACILLUS-CASEI DIHYDROFOLATE-REDUCTASE BASED ON THE X-RAY STRUCTURE OF THE ENZYME-METHOTREXATE-NADPH COMPLEX [J].

MATTHEWS, DA .

BIOCHEMISTRY, 1979, 18 (08) :1602-1610

[45]

MATTHEWS DA, 1978, J BIOL CHEM, V253, P6946

[46]

MATTHEWS DA, 1979, J BIOL CHEM, V254, P4144

[47] DIHYDROFOLATE-REDUCTASE - X-RAY STRUCTURE OF BINARY COMPLEX WITH METHOTREXATE [J].

MATTHEWS, DA ;

ALDEN, RA ;

BOLIN, JT ;

FREER, ST ;

HAMLIN, R ;

XUONG, N ;

KRAUT, J ;

POE, M ;

WILLIAMS, M ;

HOOGSTEEN, K .

SCIENCE, 1977, 197 (4302) :452-455

[48]

McPherson A Jr, 1976, Methods Biochem Anal, V23, P249, DOI 10.1002/9780470110430.ch4

[49]

NAYLOR CB, J CHEM SOC CHEM COMM

[50]

OATLEY SJ, 1982, HORMONE ANTAGONISTS, P705

← 1 2 3 4 5 6 →