OXIDATION OF ALPHA-DIAZOKETONES DERIVED FROM L-AMINO-ACIDS AND DIPEPTIDES USING DIMETHYLDIOXIRANE - SYNTHESIS AND REACTIONS OF HOMOCHIRAL N-PROTECTED ALPHA-AMINO GLYOXALS

被引：33

作者：

DARKINS, P ^{[1
]}

MCCARTHY, N ^{[1
]}

MCKERVEY, MA ^{[1
]}

YE, T ^{[1
]}

机构：

[1] QUEENS UNIV BELFAST,SCH MED,BELFAST BT9 5AG,ANTRIM,NORTH IRELAND

来源：

JOURNAL OF THE CHEMICAL SOCIETY-CHEMICAL COMMUNICATIONS | 1993年 / 15期

关键词：

D O I：

10.1039/c39930001222

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Homochiral N-protected alpha-amino glyoxals are readily accessible by oxidation of alpha-diazoketones derived from natural amino acids and dipeptides using dimethyldioxirane in acetone; the glyoxals can be trapped efficiently in reactions such as Wittig olefination and condensation with amines and vicinal diamines.

引用

页码：1222 / 1223

页数：2

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