NITRATE, NITRITE AND N-NITROSO COMPOUNDS

被引:298
作者
GANGOLLI, SD
VANDENBRANDT, PA
FERON, VJ
JANZOWSKY, C
KOEMAN, JH
SPEIJERS, GJA
SPIEGELHALDER, B
WALKER, R
WISHNOK, JS
机构
[1] TOXICOL ADVISORY SERV,SUTTON,SURREY,ENGLAND
[2] UNIV LIMBURG,DEPT EPIDEMIOL,6200 MD MAASTRICHT,NETHERLANDS
[3] TNO,INST TOXICOL & NUTR,3700 AJ ZEIST,NETHERLANDS
[4] UNIV KAISERSLAUTERN,W-6750 KAISERSLAUTERN,GERMANY
[5] AGR UNIV WAGENINGEN,DEPT TOXICOL,WAGENINGEN,NETHERLANDS
[6] NATL INST PUBL HLTH & ENVIRONM PROTECT,TOXICOL LAB,3720 BA BILTHOVEN,NETHERLANDS
[7] DEUTSCH KREBSFORSCHUNGSZENTRUM,W-6900 HEIDELBERG,GERMANY
[8] UNIV SURREY,SCH BIOL SCI,FOOD SAFETY GRP,GUILDFORD,SURREY,ENGLAND
[9] MIT,DIV TOXICOL,CAMBRIDGE,MA 02139
来源
EUROPEAN JOURNAL OF PHARMACOLOGY-ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY SECTION | 1994年 / 292卷 / 01期
关键词
NITRATE; NITRITE; N-NITROSO COMPOUND; HUMAN DIET; DIETARY INTAKE; ENDOGENOUS SYNTHESIS; METABOLISM; TOXICOKINETICS; ANIMAL TOXICOLOGY; HUMAN EFFECTS; EPIDEMIOLOGY; RISK ASSESSMENT;
D O I
10.1016/0926-6917(94)90022-1
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
A risk assessment has been made on nitrate, nitrite and N-nitroso compounds encountered in the human diet. Vegetables constitute a major source of nitrate providing over 85% of the average daily human dietary intake. Nitrite and N-nitroso compounds present in the diet contribute relatively small amounts to the body burden and the major source of these biologically reactive compounds is derived from the bacterial and mammalian metabolism of ingested nitrate. Additionally, endogenous synthesis provides an important source contributing to the body burden of nitrate. Data from animal toxicological studies, human effects and epidemiological surveys have been reviewed and evaluated. It is concluded that there is no firm scientific evidence at present to recommend drastic reductions beyond the average levels of nitrate encountered in vegetables grown in keeping with good agricultural practice. Recommendations have also been made for further animal and human studies to be carried out to elucidate the potential risks to man from ingested nitrate.
引用
收藏
页码:1 / 38
页数:38
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