ION SELECTIVITY OF BA-2+ INWARD CURRENT OSCILLATIONS IN RAS-TRANSFORMED FIBROBLASTS THAT ELICIT CYTOPLASMIC CA-2+ OSCILLATIONS BY BRADYKININ

被引：1

作者：

HIGASHIDA, H ^{[1
]}

SHAHIDULLAH, M ^{[1
]}

HOSHI, N ^{[1
]}

NODA, M ^{[1
]}

HASHII, M ^{[1
]}

ZHONG, ZG ^{[1
]}

NOZAWA, Y ^{[1
]}

机构：

[1] GIFU UNIV,SCH MED,DEPT BIOCHEM,GIFU 500,JAPAN

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1992年 / 185卷 / 01期

关键词：

D O I：

10.1016/S0006-291X(05)80970-2

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Ion selectivity of divalent cations on Ba2+ inward current oscillations was examined by voltage-clamp recording in ν-Ki-ras-transformed NIH/3T3 (DT) fibroblasts where repetitive transient increases in cytoplasmic Ca2+ concentration were evoked by bradykinin. Application of bradykinin onto DT cells in 50 mM Ba2+ solution initiated Ba2+ inward current oscillations. The inward currents were inhibited in equimolar Sr2+ or Ca2+ solutions. Ba2+ current oscillations were dependent upon extracellular Ba2+ concentration. The results suggest that inward current oscillations are highly selective to Ba2+. © 1992 Academic Press, Inc.

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页码：162 / 166

页数：5

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