The molecular biology of SRY and its role in sex determination in mammals

被引:26
作者
Koopman, P
机构
[1] Centre for Molecular and Cellular Biology, The University of Queensland, Brisbane, QLD
关键词
D O I
10.1071/RD9950713
中图分类号
Q [生物科学];
学科分类号
07 ; 0710 ; 09 ;
摘要
SRY is the gene that initiates the genetic cascade leading to testis development in mammals. Since its discovery in 1990 and the direct demonstration of its male-determining role in transgenic mice, attention has turned to understanding the biochemical mode of action of the SRY gene product, and to the identification of other genes in the sex-determining pathway. Recent progress in these efforts is summarized in this review.
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页码:713 / 722
页数:10
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