New antiepileptic drugs: Prospects for the future

被引：13

作者：

Britton, JW

So, EL

机构：

[1] Division of Epilepsy, Department of Neurology, Mayo Clinic, Rochester, MN

来源：

JOURNAL OF EPILEPSY | 1995年 / 8卷 / 04期

关键词：

antiepileptic drugs; vigabatrin; lamotrigine; tiagabine; topiramate; zonisamide; oxcarbamazepine; fosphenytoin; pharmacology; pharmacokinetics; epilepsy treatment;

D O I：

10.1016/0896-6974(95)00049-6

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Considerable advances have been made in the understanding of the pathophysiology of epilepsy, which has led to the development of a large number of unique antiepileptic drugs affecting a broader array of pharmacological targets than traditional anticonvulsants. In this paper we discuss seven anticonvulsants that are either recently released, or are being actively investigated in the United States. A review of their pharmacological properties and clinical efficacy is presented.

引用

收藏

页码：267 / 281

页数：15

相关论文

共 243 条

[61]

Gaily Eija, 1994, Epilepsia, V35, P93

[62] GABA IN EPILEPSY - THE PHARMACOLOGIC BASIS [J].

GALE, K .

EPILEPSIA, 1989, 30 :S1-S11

[63] SAFETY, TOLERANCE AND PHARMACOKINETICS OF INTRAVENOUS DOSES OF THE PHOSPHATE ESTER OF 3-HYDROXYMETHYL-5,5-DIPHENYLHYDANTOIN - A NEW PRODRUG OF PHENYTOIN [J].

GERBER, N ;

MAYS, DC ;

DONN, KH ;

LADDU, A ;

GUTHRIE, RM ;

TURLAPATY, P ;

QUON, CY ;

RIVENBURG, WK .

JOURNAL OF CLINICAL PHARMACOLOGY, 1988, 28 (11) :1023-1032

[64] VIGABATRIN IN INTRACTABLE CHILDHOOD EPILEPSY - A RETROSPECTIVE STUDY [J].

GIBBS, JM ;

APPLETON, RE ;

ROSENBLOOM, L .

PEDIATRIC NEUROLOGY, 1992, 8 (05) :338-340

[65] CHRONIC TOXICITY STUDIES WITH VIGABATRIN, A GABA-TRANSAMINASE INHIBITOR [J].

GIBSON, JP ;

YARRINGTON, JT ;

LOUDY, DE ;

GERBIG, CG ;

HURST, GH ;

NEWBERNE, JW .

TOXICOLOGIC PATHOLOGY, 1990, 18 (02) :225-238

[66] EFFECT OF VIGABATRIN ON SEDATION AND COGNITIVE FUNCTION IN PATIENTS WITH REFRACTORY EPILEPSY [J].

GILLHAM, RA ;

BLACKLAW, J ;

MCKEE, PJW ;

BRODIE, MJ .

JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY, 1993, 56 (12) :1271-1275

[67] LAMOTRIGINE - A REVIEW OF ITS PHARMACOLOGICAL PROPERTIES AND CLINICAL EFFICACY IN EPILEPSY [J].

GOA, KL ;

ROSS, SR ;

CHRISP, P .

DRUGS, 1993, 46 (01) :152-176

[68]

GRAHAM D, 1989, PHARMACOLOGY, V27, pS43

[69] GAMMA-VINYL GABA - A DOUBLE-BLIND PLACEBO-CONTROLLED TRIAL IN PARTIAL EPILEPSY [J].

GRAM, L ;

KLOSTERSKOV, P ;

DAM, M .

ANNALS OF NEUROLOGY, 1985, 17 (03) :262-266

[70]

GRAM L, 1989, ANTIEPILEPTIC DRUGS, P947

← 2 3 4 5 6 7 8 9 10 11 →