FREE D-SERINE, D-ASPARTATE AND D-ALANINE IN CENTRAL-NERVOUS-SYSTEM AND SERUM IN MUTANT MICE LACKING D-AMINO-ACID OXIDASE

被引：183

作者：

HASHIMOTO, A

NISHIKAWA, T

KONNO, R

NIWA, A

YASUMURA, Y

OKA, T

TAKAHASHI, K

机构：

[1] RES DEV CORP JAPAN,PRECURSORY RES EMBRYON SCI & TECHNOL GRP,TOKYO,JAPAN

[2] DOKKYO UNIV,SCH MED,DEPT MICROBIOL,MIBU,TOCHIGI 32102,JAPAN

来源：

NEUROSCIENCE LETTERS | 1993年 / 152卷 / 1-2期

关键词：

D-SERINE; D-ALANINE; D-AMINO ACID OXIDASE; STRYCHNINE-INSENSITIVE GLYCINE SITE; N-METHYL-D-ASPARTATE RECEPTOR; MUTANT DDY/DAO-MOUSE;

D O I：

10.1016/0304-3940(93)90476-2

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

We have examined whether D-amino acid oxidase (DAO) regulates free D-Serine content using mutant ddY/DAO- mice lacking DAO activity. We find that the content of D-serine in the serum and cerebellum of mutant mice is much higher than that of normal mice, whereas a slight but significant difference in the cerebral D-serine level is observed between the two strains. These results suggest that, although DAO may participate in the catabolism Of D-serine in the cerebellum and periphery, there appears to be other mechanisms for catabolism of endogenous D-serine in the brain.

引用

页码：33 / 36

页数：4

共 26 条

[11] REQUIREMENT FOR GLYCINE IN ACTIVATION OF NMDA-RECEPTORS EXPRESSED IN XENOPUS OOCYTES [J].