LYCORICIDINE AND PANCRATISTATIN ANALOGS FROM CYCLOPENTADIENE

被引:62
作者
BANWELL, MG [1 ]
COWDEN, CJ [1 ]
GABLE, RW [1 ]
机构
[1] AUSTRALIAN NATL UNIV,RES SCH CHEM,CANBERRA,ACT 0200,AUSTRALIA
来源
JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1 | 1994年 / 24期
关键词
D O I
10.1039/p19940003515
中图分类号
O62 [有机化学];
学科分类号
070303 ; 081704 ;
摘要
Concise synthetic routes from cyclopentadiene 4 to the lycoricidine and pancratistatin analogues 13. 14 and 17 have been developed.:The key step involved the silver isocyanate promoted ring opening of the gem-dibromocyclopropane 6 to give, after interception of the intermediate isocyanates by added methanol, the carbamates 7 and 8. The X-ray crystal structures of compounds 13 and 16 have been determined.
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页码:3515 / 3518
页数:4
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