TAXOL CHEMISTRY - 7-O-TRIFLATES AS PRECURSORS TO OLEFINS AND CYCLOPROPANES

被引：36

作者：

JOHNSON, RA

NIDY, EG

DOBROWOLSKI, PJ

GEBHARD, I

QUALLS, SJ

WICNIENSKI, NA

KELLY, RC

机构：

[1] Upjohn Laboratories, The Upjohn Company, Kalamazoo

来源：

TETRAHEDRON LETTERS | 1994年 / 35卷 / 43期

关键词：

D O I：

10.1016/0040-4039(94)80004-9

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

7-O-Triflates of baccatin III or of taxol analogs are convenient precursors in alternate syntheses of Delta(6,7)-taxols and 7 beta,8 beta-methano (cyclopropyl) taxols, two of the products initially obtained from reaction of taxols with methylDAST; hydrazine is an effective reagent for conversion of the 10-acetate group to the hydroxyl group.

引用

页码：7893 / 7896

页数：4

共 15 条

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[3] SERENDIPITOUS SYNTHESIS OF A CYCLOPROPANE-CONTAINING TAXOL ANALOG VIA ANCHIMERIC PARTICIPATION OF AN UNACTIVATED ANGULAR METHYL-GROUP
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[5] 2-MONOSUBSTITUTED-1,3-OXAZOLIDINES AS IMPROVED PROTECTIVE GROUPS OF N-BOC-PHENYLISOSERINE IN DOCETAXEL PREPARATION
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