CHROMOSOMAL MAPPING OF THE GENES GPRK5 AND GPRK6 ENCODING G-PROTEIN-COUPLED RECEPTOR KINASES GRK5 AND GRK6

被引：12

作者：

BULLRICH, F

DRUCK, T

KUNAPULI, P

GOMEZ, J

GRIPP, KW

SCHLEGELBERGER, B

LASOTA, J

ARONSON, M

CANNIZZARO, LA

HUEBNER, K

BENOVIC, JL

机构：

[1] THOMAS JEFFERSON UNIV,JEFFERSON CANC INST,DEPT PHARMACOL,PHILADELPHIA,PA 19107

[2] THOMAS JEFFERSON UNIV,JEFFERSON CANC INST,DEPT MICROBIOL & IMMUNOL,PHILADELPHIA,PA 19107

[3] CHRISTIAN ALBRECHTS UNIV KIEL,KIEL,GERMANY

来源：

CYTOGENETICS AND CELL GENETICS | 1995年 / 70卷 / 3-4期

关键词：

D O I：

10.1159/000134045

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

G protein-coupled receptor kinases (GRKs) play an important role in phosphorylating and regulating the activity of a variety of G protein-coupled receptors. Chromosomal mapping of the human genes for the two most recently identified members of the GRK family, GRKS (GPRK5) and GRK6 (GPRK6), was accomplished by correlation of the presence of the GPRK5 and GPRK6 loci with specific chromosome regions in a rodent-human hybrid panel. These analyses revealed that GPRK5 maps to chromosome region 10q24-->qter while GPRK6 maps to 5q35. A GPRK6 related locus maps to 13pter-->q21.

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页码：250 / 254

页数：5

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