DECREASE IN CYTOSOLIC ASPARTYL-AMINOPEPTIDASE BUT NOT IN ALANYL-AMINOPEPTIDASE ACTIVITY IN THE FRONTAL-CORTEX OF THE AGED RAT

被引：12

作者：

IRIBAR, C ^{[1
]}

ESTEBAN, MJ ^{[1
]}

MARTINEZ, JM ^{[1
]}

PEINADO, JM ^{[1
]}

机构：

[1] UNIV GRANADA,SCH MED,INST NEUROSCI,DEPT PHYSIOL,E-18010 GRANADA,SPAIN

来源：

BRAIN RESEARCH | 1995年 / 687卷 / 1-2期

关键词：

AMINOPEPTIDASE; EXCITATORY AMINO ACID; AGING; BETA-AMYLOID PEPTIDE; NEUROPEPTIDE;

D O I：

10.1016/0006-8993(95)00538-2

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

To test the neurotoxic hypothesis of excitatory amino acids, we evaluated the possible contribution to the free acidic amino acid pool of Aspartyl-aminopeptidase activity in the frontal cortex of adult (3 month old) and aged rats (3 groups of animals aged 26, 29 and 33 months). Aspartyl-aminopeptidase activity showed a significant decrease in the oldest rats (29 and 33 months old) whereas the activity of Alanyl-aminopeptidase, an unspecific enzyme, did not change with age. These data invalidate the idea that excess free acidic amino acids are released by aminopeptidases in the aged rat but do provide evidence of age-related changes in this enzymatic activity. The possible implications of our findings for general alterations in protein degradation are discussed.

引用

页码：211 / 213

页数：3

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