QUANTITATIVE STRUCTURE ACTIVITY RELATIONSHIP OF ANTIFOLATE INHIBITION OF BACTERIA CELL-CULTURES RESISTANT AND SENSITIVE TO METHOTREXATE

被引：18

作者：

COATS, EA

GENTHER, CS

SELASSIE, CD

STRONG, CD

HANSCH, C

机构：

[1] UNIV CINCINNATI,MED CTR,COLL PHARM,CINCINNATI,OH 45267

[2] POMONA COLL,DEPT CHEM,CLAREMONT,CA 91711

来源：

JOURNAL OF MEDICINAL CHEMISTRY | 1985年 / 28卷 / 12期

关键词：

D O I：

10.1021/jm00150a026

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

引用

页码：1910 / 1916

页数：7

共 19 条

[1] STRUCTURE ACTIVITY RELATIONSHIPS OF DIHYDROFOLATE-REDUCTASE INHIBITORS
BLANEY, JM
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SILIPO, C
VITTORIA, A
[J]. CHEMICAL REVIEWS, 1984, 84 (04) : 333 - 407
[2] BOLIN JT, 1982, J BIOL CHEM, V257, P13650
[3] COMPARISON OF THE INHIBITION OF METHOTREXATE-SENSITIVE AND METHOTREXATE-RESISTANT LACTOBACILLUS-CASEI CELL-CULTURES WITH PURIFIED LACTOBACILLUS-CASEI DIHYDROFOLATE-REDUCTASE BY 4,6-DIAMINO-1,2-DIHYDRO-2,2-DIMETHYL-1-(3-SUBSTITUTED-PHENYL)-S-TRIAZINES - USE OF QUANTITATIVE STRUCTURE-ACTIVITY-RELATIONSHIPS IN MAKING INFERENCES ABOUT THE MECHANISM OF RESISTANCE AND THE STRUCTURE OF THE ENZYME INSITU COMPARED WITH THE ENZYME INVITROUA
COATS, EA
GENTHER, CS
DIETRICH, SW
GUO, Z
HANSCH, C
[J]. JOURNAL OF MEDICINAL CHEMISTRY, 1981, 24 (12) : 1422 - 1429
[4] QUANTITATIVE STRUCTURE-SELECTIVITY RELATIONSHIPS - COMPARISON OF THE INHIBITION OF ESCHERICHIA-COLI AND BOVINE LIVER DIHYDROFOLATE-REDUCTASE BY 5-(SUBSTITUTED-BENZYL)-2,4-DIAMINOPYRIMIDINES
DIETRICH, SW
BLANEY, JM
REYNOLDS, MA
JOW, PYC
HANSCH, C
[J]. JOURNAL OF MEDICINAL CHEMISTRY, 1980, 23 (11) : 1205 - 1212
[5] USE OF TRIAZINE INHIBITORS IN MAPPING THE ACTIVE-SITE REGION OF LACTOBACILLUS-CASEI DIHYDROFOLATE-REDUCTASE
DIETRICH, SW
SMITH, RN
BRENDLER, S
HANSCH, C
[J]. ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS, 1979, 194 (02) : 612 - 619
[6] RHO-SIGMA-PI ANALYSIS . METHOD FOR CORRELATION OF BIOLOGICAL ACTIVITY + CHEMICAL STRUCTURE
HANSCH, C
FUJITA, T
[J]. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1964, 86 (08) : 1616 - &
[7] CRYSTALLOGRAPHY, QUANTITATIVE STRUCTURE ACTIVITY RELATIONSHIPS, AND MOLECULAR GRAPHICS IN A COMPARATIVE-ANALYSIS OF THE INHIBITION OF DIHYDROFOLATE-REDUCTASE FROM CHICKEN LIVER AND LACTOBACILLUS-CASEI BY 4,6-DIAMINO-1,2-DIHYDRO-2,2-DIMETHYL-1-(SUBSTITUTED-PHENYL)-S-TRIAZINESAN
HANSCH, C
HATHAWAY, BA
GUO, ZR
SELASSIE, CD
DIETRICH, SW
BLANEY, JM
LANGRIDGE, R
VOLZ, KW
KAUFMAN, BT
[J]. JOURNAL OF MEDICINAL CHEMISTRY, 1984, 27 (02) : 129 - 143
[8] Hansch C, 1979, SUBSTITUENT CONSTANT
[9] QUANTITATIVE STRUCTURE-SELECTIVITY RELATIONSHIPS - COMPARISON OF THE INHIBITION OF ESCHERICHIA-COLI AND BOVINE LIVER DIHYDROFOLATE-REDUCTASE BY 5-(SUBSTITUTED-BENZYL)-2,4-DIAMINOPYRIMIDINES
LI, RL
DIETRICH, SW
HANSCH, C
[J]. JOURNAL OF MEDICINAL CHEMISTRY, 1981, 24 (05) : 538 - 544
[10] A COMPARISON OF THE INHIBITORY-ACTION OF 5-(SUBSTITUTED-BENZYL)-2,4-DIAMINOPYRIMIDINES ON DIHYDROFOLATE-REDUCTASE FROM CHICKEN LIVER WITH THAT FROM BOVINE LIVER
LI, RL
HANSCH, C
KAUFMAN, BT
[J]. JOURNAL OF MEDICINAL CHEMISTRY, 1982, 25 (04) : 435 - 440

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