LINKAGE MAPPING OF THE ANGIOTENSIN AT(2) RECEPTOR GENE (AGTR2) TO THE MOUSE X-CHROMOSOME

被引：13

作者：

HEIN, L

DZAU, VJ

BARSH, GS

机构：

[1] STANFORD UNIV, SCH MED, HOWARD HUGHES MED INST, BECKMAN CTR B271, STANFORD, CA 94305 USA

[2] STANFORD UNIV, SCH MED, HOWARD HUGHES MED INST, STANFORD, CA 94305 USA

[3] STANFORD UNIV, SCH MED, DIV CARDIOVASC MED, STANFORD, CA 94305 USA

[4] STANFORD UNIV, SCH MED, DEPT PEDIAT, STANFORD, CA 94305 USA

[5] STANFORD UNIV, SCH MED, DEPT GENET, STANFORD, CA 94305 USA

来源：

GENOMICS | 1995年 / 30卷 / 02期

关键词：

D O I：

10.1006/geno.1995.0033

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Angiotensin II is a potent regulator of cardiovascular homeostasis and binds to two different G-protein-coupled receptors. While the type 1 receptor (AT(1)) mediates the cardiovascular actions of ansotensin II, the function of the recently cloned type 2 receptor (AT(2)) remains unknown. We have cloned the mouse AT(2) receptor gene (Agtr2) and determined its map position by linkage analysis using an interspecific backcross (C57BL/6J x Mus spretus). Agtr2 is located on the proximal mouse X chromosome between DXMit85 and DXMit49, in a region of conserved synteny with a part of the human X chromosome implicated in inherited forms of premature ovarian failure. The mapping of Agtr2 may expand a region of conserved synteny with human Xq26 that includes Hprt. (C) 1995 Academic Press, Inc.

引用

页码：369 / 371

页数：3

共 24 条

[1] NEW INSIGHTS INTO THE MAN-MOUSE COMPARATIVE MAP OF THE X-CHROMOSOME [J].