X-REGION DELETION VARIANTS OF HEPATITIS-B VIRUS IN SURFACE ANTIGEN-NEGATIVE INFECTIONS AND NON-A, NON-B-HEPATITIS

被引：32

作者：

FEITELSON, MA

DUAN, LX

GUO, J

SUN, B

WOO, J

STEENSMA, K

HORIIKE, N

BLUMBERG, BS

机构：

[1] THOMAS JEFFERSON UNIV,DEPT MED,DIV INFECT DIS,PHILADELPHIA,PA 19107

[2] FOX CHASE CANC CTR,DIV POPULAT SCI,PHILADELPHIA,PA

[3] NICHHD,BETHESDA,MD

[4] EHIME UNIV,SCH MED,DEPT INTERNAL MED 3,MATSUYAMA,EHIME 790,JAPAN

来源：

JOURNAL OF INFECTIOUS DISEASES | 1995年 / 172卷 / 03期

关键词：

D O I：

10.1093/infdis/172.3.713

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The etiology of non-A, non-B hepatitis (NANBH) in renal dialysis patients was determined. Hepatitis C virus was present in many, but its appearance did not correlate with elevated alanine aminotransaminase. When sera from these patients were tested for antibodies against hepatitis B virus (HBV) X antigen and polymerase, 70% were positive. HBV infection was confirmed by polymerase chain reaction using several HBV-specific primer pairs. However, amplification with X region primers failed to yield products in many patients. Cloning and sequencing of these products demonstrated deletions within the X region. Hence, X-deletion variants of HBV are strongly associated with NANBH in renal dialysis patients.

引用

页码：713 / 722

页数：10

共 40 条

[11] MONOCLONAL-ANTIBODIES RAISED TO PURIFIED WOODCHUCK HEPATITIS-VIRUS CORE ANTIGEN PARTICLES DEMONSTRATE X-ANTIGEN REACTIVITY [J].